51012-27-2

Basic information

• Product Name: 2,5-Bis(trifluoromethyl)benzonitrile
• Synonyms: 2,5-BIS(TRIFLUOROMETHYL)BENZONITRILE
• CAS NO: 51012-27-2
• Molecular Formula: C₉H₃F₆N
• Molecular Weight: 239.12
• Product Categories: Aromatic Nitriles
• Mol File: 51012-27-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 194
• Flash Point: 83.5 °C
• Appearance: /
• Density: 1.45 g/cm³
• Refractive Index: 1.4210
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-Bis(trifluoromethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Bis(trifluoromethyl)benzonitrile(51012-27-2)
• EPA Substance Registry System: 2,5-Bis(trifluoromethyl)benzonitrile(51012-27-2)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• Hazardous Substances Data: 51012-27-2(Hazardous Substances Data)

Usage

General Description

2,5-Bis(trifluoromethyl)benzonitrile is a chemical compound with the molecular formula C9H3F6N. It is a white crystalline solid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,5-Bis(trifluoromethyl)benzonitrile is a highly fluorinated compound, making it useful in the production of fluorinated materials and as a building block in the development of new compounds with diverse applications. It is known for its high chemical stability and resistance to degradation, making it a valuable tool in the research and development of a wide range of products. Additionally, it is used as a reagent in organic synthesis and has potential applications in the development of advanced materials and specialty chemicals.

Upstream product

• 328-93-8 2,5-bis(trifluoromethyl)aniline 
• 557-19-7 nickel cyanide 

Downstream Products

• 395-64-2 2,5-bis(trifluoromethyl)benzaldehyde 

Relevant articles and documents

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.