51012-27-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2,5-Bis(trifluoromethyl)benzonitrile is used as a key intermediate for the synthesis of various pharmaceuticals and agrochemicals, leveraging its high chemical stability and fluorination properties to enhance the performance and efficacy of the final products.
Used in the Production of Fluorinated Materials:
As a building block, 2,5-Bis(trifluoromethyl)benzonitrile is utilized in the creation of fluorinated materials, capitalizing on its fluorination to improve the properties of these materials for specific applications.
Used in Organic Synthesis as a Reagent:
2,5-Bis(trifluoromethyl)benzonitrile is employed as a reagent in organic synthesis, contributing to the development of advanced materials and specialty chemicals through its unique chemical properties.
Used in Research and Development:
2,5-Bis(trifluoromethyl)benzonitrile is used as a valuable tool in research and development, particularly for the creation of new compounds with diverse applications, owing to its stability and reactivity in chemical processes.

Upstream product

• 328-93-8 2,5-bis(trifluoromethyl)aniline 
• 557-19-7 nickel cyanide 

Downstream Products

• 395-64-2 2,5-bis(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluotomethylbenzylamine represented by the following general formula (1), 1where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4. The process includes hydrogenating a trifluoromethylbenzonitrile by hydrogen in an organic solvent in the presence of ammonia and a catalyst containing a platinum group element. This trifluoromethylbenzonitrile is represented by the following general formula (2), 2where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine at an extremely high yield.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.