51013-99-1Relevant academic research and scientific papers
CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP
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, (2020/05/19)
Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES
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Page/Page column 163, (2020/01/31)
A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
Oxidation of Alkenes and Sulfides with Transition Metal Catalysts
Liao, Jen-Hai,Cheng, Kuang-Yuan,Fang, Jim-Min,Cheng, Ming-Chu,Wang, Yu
, p. 847 - 860 (2007/10/03)
Alkenes and sulfides were oxidized with transition-metal catalysts.The oxidant sources include molecular dioxygen, air and iodosylbenzene.The metal ions Mn(III), Fe(III), Co(II) and Ni(II) were used.The catalysts 1-18 of 1,3-dioxo-, β-ketoimine- or salen-types were prepared and their efficacy was examined. 1,2-Dihydronaphthalene is most efficiently epoxidized with O2/Me2CHCHO or PhIO in the presence of Mn(III)-salen catalysts.The Ni(II)-, Co(II)- and Fe(III)-catalysts of either β-ketoimine- or salen-types are useful for epoxidation of styrene, (E)-stilbene and (E)-benzalacetone in the O2/Me2CHCHO system; these epoxidations are stereospecific without formation of corresponding diastereomeric epoxides.Oxidation of methyl p-totyl sulfide with O2/Me2CHCHO is facilitated by the 1,3-dioxo-catalyst Co(II)-1.Monooxidation is achieved with Me2CHCHO in equimolar proportions to give the corresponding sulfoxide, whereas overoxidation is realized with excess Me2CHCHO to give the sulfone.These epoxidation and sulfide oxidations all occur at 25 deg C and are complete in less than a day.Key Words: Oxidation; Transition metals; Alkenes; Sulfides; 1,3-Diketone; β-Ketoimine; Salen.
