51022-77-6 Usage
Uses
Used in Pharmaceutical Industry:
Etazolate is used as a PDE IV inhibitor for its ability to regulate the levels of cAMP and cGMP within cells. This property makes it a valuable compound in the development of drugs targeting various diseases and conditions, particularly those involving inflammation and immune response modulation.
Used in Research Applications:
In the field of scientific research, Etazolate is used as a research tool to study the role of PDE IV in cellular processes. Its selective inhibition of PDE IV allows researchers to investigate the specific effects of cAMP and cGMP on cellular functions, contributing to a better understanding of their roles in various biological pathways.
Used in Drug Development:
Etazolate's PDE IV inhibitory activity makes it a potential candidate for the development of new drugs targeting conditions such as asthma, chronic obstructive pulmonary disease (COPD), and autoimmune disorders. Its higher activity for cAMP compared to cGMP suggests that it may have a more targeted effect on specific disease pathways, potentially leading to more effective treatments with fewer side effects.
Used in Diagnostic Applications:
Due to its specificity as a PDE IV inhibitor, Etazolate can be utilized in diagnostic applications to identify and measure the activity of PDE IV in various samples. This can be particularly useful in the development of diagnostic tests for conditions where PDE IV activity is a key factor, such as certain inflammatory and autoimmune diseases.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
Check Digit Verification of cas no
The CAS Registry Mumber 51022-77-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,2 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 51022-77:
(7*5)+(6*1)+(5*0)+(4*2)+(3*2)+(2*7)+(1*7)=76
76 % 10 = 6
So 51022-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)
51022-77-6Relevant academic research and scientific papers
METHODS AND TOOLS FOR THE THERAPY OF NEURODEGENERATIVE PATHOLOGIES
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, (2009/12/28)
The present invention concerns compositions and methods for the treatment of neurodegenerative diseases in which the cognitive functions are altered, such as observed in Alzheimer's disease. More particularly, the invention presents a strategy for human clinical monitoring of the activity and/or effectiveness of neuroprotective treatments, based on biochemical assay of certain platelet parameters, and thus can be done by blood sampling. The invention also concerns methods, tools, constructions and compositions suitable for implementing these strategies
Molecular target of neurotoxicity
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, (2008/06/13)
The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterisation and/or treatment (or management) of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention equally concerns methods for identifying or screening compounds active in these diseases. The invention further concerns the compounds, genes, cells, plasmids or compositions useful for implementing the hereinabove methods. In particular, the invention describes the role of PDE4B in these diseases and its use as a therapeutic, diagnostic or experimental target.
