51028-36-5

Basic information

• Product Name: (3-Chlorophenyl)carbamic chloride
• Synonyms: (3-Chlorophenyl)carbamic chloride
• CAS NO: 51028-36-5
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.029
• Mol File: 51028-36-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.469
• CAS DataBase Reference: (3-Chlorophenyl)carbamic chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Chlorophenyl)carbamic chloride(51028-36-5)
• EPA Substance Registry System: (3-Chlorophenyl)carbamic chloride(51028-36-5)

Safety Data

• Hazardous Substances Data: 51028-36-5(Hazardous Substances Data)

Usage

General Description

(3-Chlorophenyl)carbamic chloride is a chemical compound with the molecular formula C7H6ClNO2. It is an organochlorine compound that is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (3-Chlorophenyl)carbamic chloride is a derivative of carbamic acid and is commonly used as a reagent for the preparation of carbamate esters. It is a colorless to light yellow solid with a pungent odor, and it is highly reactive and must be handled with caution. When heated to decomposition, it emits toxic fumes of hydrogen chloride and nitrogen oxides. Additionally, (3-Chlorophenyl)carbamic chloride may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation.

Upstream product

• 75-44-5 phosgene 
• 108-42-9 3-chloro-aniline 
• 2909-38-8 m-chlorophenyl isocyanate 

Downstream Products

• 2909-38-8 m-chlorophenyl isocyanate 

Relevant articles and documents

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates

Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects. Different approaches have been applied to develop strong analgesic drugs with reduced pharmacologic side-effects. One of the most promising is the design of multitarget drugs. In this paper we report the synthesis, characterization and biological evaluation of twelve new 4-anilidopiperidine (fentanyl analogues). In vivo hot-Plate test, shows a moderate antinociceptive activity for compounds OMDM585 and OMDM586, despite the weak binding affinity on both μ and δ-opioid receptors. A strong inverse agonist activity in the GTP-binding assay was revealed suggesting the involvement of alternative systems in the brain. Fatty acid amide hydrolase inhibition was evaluated, together with binding assays of cannabinoid receptors. We can conclude that compounds OMDM585 and 586 are capable to elicit antinociception due to their multitarget activity on different systems involved in pain modulation.