51036-79-4

Basic information

• Product Name: 2-(1H-IMIDAZOL-2-YL)-ETHANOL
• Synonyms: 2-(1H-IMIDAZOL-2-YL)-ETHANOL;2-(2-Imidazolyl)ethanol;1H-Imidazole-2-ethanol
• CAS NO: 51036-79-4
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Product Categories: pharmacetical
• Mol File: 51036-79-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 127 °C
• Boiling Point: 382.867 °C at 760 mmHg
• Flash Point: 185.352 °C
• Appearance: /
• Density: 1.228 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.83±0.10(Predicted)
• CAS DataBase Reference: 2-(1H-IMIDAZOL-2-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-IMIDAZOL-2-YL)-ETHANOL(51036-79-4)
• EPA Substance Registry System: 2-(1H-IMIDAZOL-2-YL)-ETHANOL(51036-79-4)

Safety Data

• Hazardous Substances Data: 51036-79-4(Hazardous Substances Data)

Usage

General Description

2-(1H-IMIDAZOL-2-YL)-ETHANOL is a chemical compound with the molecular formula C5H8N2O. It is also known as 2-(1H-imidazol-2-yl)ethanol or histamine trifluoroethylamine. 2-(1H-IMIDAZOL-2-YL)-ETHANOL is commonly used as an intermediate in the synthesis of pharmaceuticals, specifically histamine H3 receptor antagonists, which are used in the treatment of various conditions including allergic reactions, gastric acid secretion, and inflammation. 2-(1H-IMIDAZOL-2-YL)-ETHANOL is also known for its potential use in the synthesis of anti-cancer drugs and anti-microbial agents. It is considered to have a relatively low toxicity, but proper handling and storage measures should still be taken to ensure safety.

Upstream product

• 109-78-4 3-Hydroxypropionitrile 
• 90408-29-0 2-(2-hydroxyethyl)-N,N-dimethylimidazole-1-sulphonamide 

Downstream Products

• 43129-93-7 2-vinyl imidazole 
• 511532-55-1 2-[1-[4-(4-tert-butoxyphenyl)butyl]-1H-imidazol-2-yl]ethanol 
• 366016-94-6 2-(1-{3-[3-(Benzyloxy)phenyl]propyl}-1H-imidazol-2-yl)-1-ethanol 
• 864156-75-2 2-{1-[4-(4-methoxy-phenyl)-butyl]-1H-imidazol-2-yl}-ethanol 
• 851392-28-4 2-{1-[2-(4-benzyloxy-phenyl)-oxazol-4-ylmethyl]-1H-imidazol-2-yl}-ethanol 

Relevant articles and documents

Bare histidine-serine models: Implication and impact of hydrogen bonding on nucleophilicity

A new family of 2-hydroxyalk(en/yn)ylimidazoles has been evaluated as serine-histidine bare dyad models for the ring-opening reaction of L-lacOCA, a cyclic O-carboxyanhydride. These models were selected to unravel the implication of intramolecular hydrogen bonding and to substantiate its influence on the nucleophilicity of the alcohol moiety, as it is suspected to occur in enzyme active sites. Although designed to exclusively facilitate the preliminary step of proton transfer during the studied ring-opening reaction, these minimalistic models depicted a measureable increase in reactivity relative to the isolated fragments. A couple of reliable experimental and theoretical methods have been developed to readily monitor the strength of the intramolecular hydrogen bond in dilute solution. Results show that the folded conformers are the most nucleophilic species because of the intramolecular hydrogen bond. Copyright