51036-79-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-IMIDAZOL-2-YL)-ETHANOL is used as an intermediate in the synthesis of histamine H3 receptor antagonists for the treatment of various conditions such as allergic reactions, gastric acid secretion, and inflammation. Its role in the development of these antagonists is crucial for managing a range of health issues related to histamine activity.
Used in Anti-Cancer Drug Synthesis:
2-(1H-IMIDAZOL-2-YL)-ETHANOL is utilized as a key component in the synthesis of anti-cancer drugs, where it contributes to the development of novel therapeutic agents that target cancer cells. Its potential in this area highlights its importance in advancing cancer treatment options.
Used in Anti-Microbial Agent Synthesis:
In the field of microbiology, 2-(1H-IMIDAZOL-2-YL)-ETHANOL is employed as a precursor in the creation of anti-microbial agents. Its use in this context is aimed at enhancing the arsenal of treatments available to combat microbial infections and resistance.

Upstream product

• 109-78-4 3-Hydroxypropionitrile 
• 90408-29-0 2-(2-hydroxyethyl)-N,N-dimethylimidazole-1-sulphonamide 

Downstream Products

• 43129-93-7 2-vinyl imidazole 
• 851392-28-4 2-{1-[2-(4-benzyloxy-phenyl)-oxazol-4-ylmethyl]-1H-imidazol-2-yl}-ethanol 
• 864156-75-2 2-{1-[4-(4-methoxy-phenyl)-butyl]-1H-imidazol-2-yl}-ethanol 
• 366016-94-6 2-(1-{3-[3-(Benzyloxy)phenyl]propyl}-1H-imidazol-2-yl)-1-ethanol 
• 511532-55-1 2-[1-[4-(4-tert-butoxyphenyl)butyl]-1H-imidazol-2-yl]ethanol 

Relevant academic research and scientific papers

Bare histidine-serine models: Implication and impact of hydrogen bonding on nucleophilicity

A new family of 2-hydroxyalk(en/yn)ylimidazoles has been evaluated as serine-histidine bare dyad models for the ring-opening reaction of L-lacOCA, a cyclic O-carboxyanhydride. These models were selected to unravel the implication of intramolecular hydrogen bonding and to substantiate its influence on the nucleophilicity of the alcohol moiety, as it is suspected to occur in enzyme active sites. Although designed to exclusively facilitate the preliminary step of proton transfer during the studied ring-opening reaction, these minimalistic models depicted a measureable increase in reactivity relative to the isolated fragments. A couple of reliable experimental and theoretical methods have been developed to readily monitor the strength of the intramolecular hydrogen bond in dilute solution. Results show that the folded conformers are the most nucleophilic species because of the intramolecular hydrogen bond. Copyright

5-(1-(IMIDAZOL)METHYL)-3,3-DISUBSTITUTED-2(3H)FURANONE DERIVATIVES

Furanone compounds and compositions having anticholinergic activity are described. The compounds have the formula: STR1 wherein: the dashed line indicates either the 4,5-unsaturated or the 4,5-dihydrofuranone ring;R 1 and R 2 may be the same or different and are hydrogen, thienyl, furanyl, or cycloalkyl (C. sub.3-C 6), benzyl, phenyl, substituted phenyl or substituted benzyl wherein the phenyl or benzyl group may be substituted with halogen, trifluoromethyl, lower alkyl, lower alkoxy or hydroxy;R. sub.3, R 4 and R 5 may be the same or different and are hydrogen, lower alkyl, lower alkyl substituted with a halogen, alkoxy, amino or carboxylic acid group, an alkyl or alkylene bridge between R 4 and R. sub.5 or R 3 and the ring N, trifluoromethyl, nitro, a cycloalkyl group containing 3 to 6 carbons, halogen, benzyl, phenyl, substituted phenyl or substituted benzyl, for which the substituents are the same as those set forth for R 1 and R 2 substituted benzyl or phenyl.R 6 in the dihydrofuranone series is hydrogen or lower alkyl.Also described are the pharmaceutically acceptable quaternary alkyl and acid addition salts of such compounds. The compounds are particularly useful in the treatment of neurogenic bladder disorder and chronic obstructive pulmonary diseases.