51047-54-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(6-METHOXY-PYRIDIN-2-YL)-PIPERAZINE is used as a potential drug candidate for its pharmacological properties, which may contribute to the development of new therapeutic agents. Its unique chemical structure allows for further research and exploration of its potential applications in treating various diseases and conditions.
Used in Medicinal Chemistry Research:
1-(6-METHOXY-PYRIDIN-2-YL)-PIPERAZINE serves as an intermediate for the synthesis of biologically active molecules, enabling the creation of novel compounds with potential therapeutic effects. Its versatile chemical structure allows for modifications and optimizations to enhance its pharmacological properties and improve its efficacy as a drug candidate.
Used in Drug Development:
1-(6-METHOXY-PYRIDIN-2-YL)-PIPERAZINE is utilized in drug development processes to explore its potential as a lead compound for the treatment of various medical conditions. Its unique properties and structural features make it an interesting compound for further research, optimization, and development into effective therapeutic agents.

InChI:InChI=1/C10H15N3O/c1-14-10-4-2-3-9(12-10)13-7-5-11-6-8-13/h2-4,11H,5-8H2,1H3

Upstream product

• 2402-78-0 2,6-dichloropyridine 
• 110-85-0 piperazine 
• 17228-64-7 6-chloro-2-methoxypyridine 

Downstream Products

• 86523-93-5 N-(4-Amino-phenyl)-3-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-propionamide 
• 86546-13-6 N-(2-Amino-phenyl)-3-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-propionamide 
• 331767-37-4 9-{4-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-methoxybenzyl-amide 
• 331767-36-3 9-{4-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide 
• 86524-02-9 3-[4-(6-Methoxy-pyridin-2-yl)-piperazin-1-yl]-N-(2-nitro-phenyl)-propionamide 
• 86523-99-1 3-[4-(6-Methoxy-pyridin-2-yl)-piperazin-1-yl]-N-(4-nitro-phenyl)-propionamide 

Relevant academic research and scientific papers

Novel Aryl Piperazine Derivatives With Medical Utility

This invention provides novel aryl piperazine derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, D2-like and 5-HT2 receptor subtypes, and in particular u

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

REMEDIES OR PREVENTIVES FOR AIDS

The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing as its active ingredients one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor.

Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent

Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): STR1 wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.

Amines useful in producing pharmaceutically active CNS compounds

Disclosed are Δ9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), Δ16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), Δ17(20) -steroids (Va and Vb) and Δ9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.

Amines useful in producing pharmaceutically active CNS compounds

Disclosed are Δ9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), Δ16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), Δ17(20) -steroids (Va and Vb) and Δ9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.

1-indolyalkyl-4-(substituted-pyridinyl)piperazines

A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as antidepressant agents.

C20 Through C26 amino steroids

Disclosed are Δ9 (11)-steroids (VI) and amino substituted steroids of formula (XI) which contain an amino group attached to the terminal carbon atom of the C17-side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), Δ16 (11)-steroids (IIIa and IIIb), reduced A-ring steroids (IV), Δ17 (20)-steroids (Va and Vb) and Δ9 (11)-steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.

6-Alkoxy-N,N-disubstituted-2-pyridinamines as Anticonvulsant Agents

The anticonvulsant effect of a series of 6-alkoxy-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the activity/side-effect ratio in this series of compounds. The most desirable profile was seen with 1-piperazine, 6, and this compound was selected for a more complete pharmacological evaluation. Overall, 6 has a pharmacological profile that is very similar to that of diphenylhydantoin (phenytoin). While nearly equipotent to phenytoin, animal studies suggest a fairly short duration of action. In addition, 6 exhibited some troublesome side effects including central nervous system depression and hypothermia.