51069-26-2 Usage
Uses
Used in Pharmaceutical Industry:
Methyl quinuclidine-4-carboxylate is used as a reactant for the synthesis of oxadiazole and indolyloxadiazole 5-HT3 hydroxytryptamine (5-HT3) antagonists. These antagonists are important in the development of medications targeting the 5-HT3 receptor, which plays a crucial role in various physiological processes, including serotonin signaling and the regulation of nausea and vomiting.
In the synthesis of these antagonists, Methyl quinuclidine-4-carboxylate contributes to the formation of the core structure of the compounds, allowing for the attachment of various functional groups that can modulate the activity and selectivity of the final product. This makes it a valuable component in the design and production of novel therapeutic agents with potential applications in treating a range of conditions, such as chemotherapy-induced nausea and vomiting, irritable bowel syndrome, and other disorders related to serotonin signaling.
Check Digit Verification of cas no
The CAS Registry Mumber 51069-26-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,6 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 51069-26:
(7*5)+(6*1)+(5*0)+(4*6)+(3*9)+(2*2)+(1*6)=102
102 % 10 = 2
So 51069-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO2/c1-12-8(11)9-2-5-10(6-3-9)7-4-9/h2-7H2,1H3
51069-26-2Relevant academic research and scientific papers
Method for synthesizing intermediate of high-purity Umeclidinium bromide
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Paragraph 0061; 0065-0067, (2020/08/18)
The invention discloses a method for synthesizing intermediates 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylic ester of Umeclidinium bromide, and particularly discloses a method for synthesizing an intermediate 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylic ester of Umeclidinium bromide. According to the method, crude products of the intermediates 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylate are purified in a molecular distillation or reduced pressure distillation mode, and the high-purity medical intermediates are obtained. Thepurification cost can be effectively reduced through molecular distillation or vacuum distillation, the yield is improved, and the product purity can reach 99% or above. According to the present invention, with the synthesis method, the 1-(2-chloroethyl) piperidine-4-formate and the quinuclidin-4-carboxylate are prepared, the process route is short, the amplified production is easy, and the yieldis high. The method has the characteristics of novel process, high yield, low cost, high product purity and the like.
