51069-90-0

Basic information

• Product Name: 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97
• Synonyms: 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97;6-Bromo-4-chloro-3-formylcoumarin 97%
• CAS NO: 51069-90-0
• Molecular Formula: C₁₀H₄BrClO₃
• Molecular Weight: 287.496
• Product Categories: Building Blocks;Coumarins;CoumarinsHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 51069-90-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 163-167 °C(lit.)
• Boiling Point: 425 °C at 760 mmHg
• Flash Point: 210.8 °C
• Appearance: /
• Density: 1.85 g/cm³
• Vapor Pressure: 1.98E-07mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97(51069-90-0)
• EPA Substance Registry System: 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97(51069-90-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 51069-90-0(Hazardous Substances Data)

Usage

General Description

6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97 is a chemical compound with a molecular formula C10H5BrClO3. It is a coumarin derivative that contains bromine, chlorine, and a formyl group. 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97 is often used in the synthesis of pharmaceuticals and agrochemicals due to its potential pharmacological and biological activities. It can also be used as a fluorescent label for various biological studies and as a building block in organic synthesis. 6-BROMO-4-CHLORO-3-FORMYLCOUMARIN 97 is a versatile chemical with potential applications in various areas of chemistry and biology.

InChI:InChI=1/C10H4BrClO3/c11-5-1-2-8-6(3-5)9(12)7(4-13)10(14)15-8/h1-4H

Upstream product

• 106-41-2 4-bromo-phenol 
• 1927-95-3 4-bromophenyl acetate 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 4139-61-1 6-bromo-4-hydroxycoumarin 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1561996-95-9 2-bromo-12-(4-methoxybenzoyl)-9,10-dihydro-6H-chrom-eno-[4,3-d]imidazo[1,2-a]pyridin-6-one 
• 1561996-94-8 2-bromo-12-(4-methylbenzoyl)-9,10-dihydro-6H-chromeno [4,3-d]imidazo[1,2-a]pyridin-6-one 
• 1561996-92-6 12-benzoyl-2-bromo-9,10-dihydro-6H-chromeno[4,3-d]imidazo[1,2-a]pyridin-6-one 
• 1561996-89-1 2-bromo-12-(4-chlorobenzoyl)-9,10-dihydro-6H-chromeno [4,3-d]imidazo[1,2-a]pyridin-6-one 
• 1561996-87-9 2-bromo-12-(4-fluorobenzoyl)-9,10-dihydro-6H-chromeno [4,3-d]imidazo[1,2-a]pyridin-6-one 

Relevant articles and documents

Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates

Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.