51072-64-1

Basic information

• Product Name: 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE
• Synonyms: 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE;2-Bromo-4,5-dimethoxybenzenesulponyl chloride;2-Bromo-4,5-dimethoxysulfonyl chloride;2-BROMO-4,5-DIMETHOXYBENZENE-1-SULFONYL CHLORIDE
• CAS NO: 51072-64-1
• Molecular Formula: C₈H₈BrClO₄S
• Molecular Weight: 315.57
• Mol File: 51072-64-1.mol

Chemical Properties

• Boiling Point: 391.3°C at 760 mmHg
• Flash Point: 190.5°C
• Appearance: /
• Density: 1.658g/cm³
• Vapor Pressure: 5.61E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE(51072-64-1)
• EPA Substance Registry System: 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE(51072-64-1)

Safety Data

• Hazardous Substances Data: 51072-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications. Its ability to introduce the sulfonyl chloride functional group into organic molecules facilitates the creation of complex organic compounds with specific biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE is utilized as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its role in the formation of sulfonyl chloride-containing compounds aids in the development of effective crop protection agents that can combat various pests and weeds.
Used as a Reagent in Organic Synthesis:
2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE is employed as a reagent in organic synthesis, where it acts as a sulfonating agent. Its introduction of the sulfonyl chloride functional group into organic molecules allows for the formation of a wide range of complex organic compounds, expanding the scope of chemical research and development.
Overall, 2-BROMO-4,5-DIMETHOXY-BENZENESULFONYL CHLORIDE is a multifaceted chemical compound with applications spanning across the pharmaceutical, agrochemical, and organic synthesis industries, making it an indispensable component in the development of innovative and effective products.

InChI:InChI=1/C8H8BrClO4S/c1-13-6-3-5(9)8(15(10,11)12)4-7(6)14-2/h3-4H,1-2H3

Upstream product

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Downstream Products

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• 1218787-86-0 1-(2-bromo-4,5-dimethoxybenzenesulfonyl)-2,4,5,6,7,7a-hexahydro-1H-indole 
• 108612-36-8 6,7-dimethoxy-2-phenyl-4H-thiochromen-4-one 
• 1567388-45-7 C₁₈H₂₄BrNO₄S 
• 1610528-82-9 1-(3,4-dimethoxybenzenesulfonyl)-1,2,3,4-tetrahydropyridine 
• 1286984-62-0 1-(2-bromo-4,5-dimethoxybenzenesulfonyl)piperidine 
• 540514-29-2 4-((2-bromo-4,5-dimethoxyphenyl)sulfonyl)morpholine 
• 1610528-81-8 4-(3,4-dimethoxybenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine 
• 1610528-83-0 1-(3,4-dimethoxybenzenesulfonyl)-2,3,4,5-tetrahydroazepine 
• 496014-24-5 1-(2-bromo-4,5-dimethoxybenzenesulfonyl)azepane 
• 1451454-35-5 trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-(2-bromo-4,5-dimethoxybenzene)sulfonamide 
• 1427435-77-5 2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide 
• 1428555-18-3 C₂₁H₂₄BrF₃N₂O₅S 

Relevant articles and documents

Nickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- And 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes

A nickel-catalyzed one-pot carbonylation reaction of 2-bromobenzenesulfonyl chlorides with alkynes for the synthesis of thiochromenones has been established. Both terminal and internal alkynes were suitable substrates in this carbonylative transformation, and a broad range of 2-mono- and 2,3-disubstituted thiochromenone products were obtained in moderate to good yields with quite high functional group compatibility. Notably, this procedure presents the first example of nickel-catalyzed carbonylative synthesis of thiochromenones with 2-bromobenzenesulfonyl chlorides as a promising sulfur precursor.

Palladium-catalysed dehydrogenative sp3 C-H bonds functionalisation into alkenes: A direct access to N-alkenylbenzenesulfonamides

The palladium-catalysed dehydrogenation of sp3 carbon-hydrogen bonds of N-alkylbenzenesulfonamides allows a simple access to N-alkenylbenzenesulfonamides. The reaction proceeds with easily accessible catalysts, with pivalate as a base, and allo

Halonium ion triggered rearrangement of unsaturated benzo-annulated bi- and tricyclic sulfonamides

The halonium ion mediated 1,2-Wagner-Meerwein-type rearrangement of a series of benzo-fused bi- and tricyclic sulfonamides is reported. During this rearrangement the carbon-carbon bond that migrates was selectively set in the intramolecular Mizoroki-Heck

Double reduction of cyclic aromatic sulfonamides: A novel method for the synthesis of 2- and 3-aryl-substituted cyclic amines

(Chemical Equation Presented) The facile double reduction of bicyclic aromatic sulfonamides was used to synthesize a variety of 2- and 3-aryl-substituted pyrrolidines and 2-phenylpiperidine. The method features a combined nitrogen protection and a traceless tether for the transposition of the aromatic moiety from nitrogen to carbon.

Urotensin-II receptor antagonists

P51084 The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.