510774-50-2

Usage

Uses

Used in Biological Research:
8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a research tool for studying the interaction between TCL1 and Epac1 in the activation of Akt kinases. This interaction occurs in the plasma membranes and nuclei of macrophages stimulated by 8-CPT-2-O-Me-cAMP, providing valuable insights into cellular signaling mechanisms and potential therapeutic targets.
Used in Pharmaceutical Development:
As an activator of the Epac cAMP receptor, 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT may have potential applications in the development of drugs targeting specific signaling pathways. By modulating the activity of Epac1 and its downstream effectors, 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT could contribute to the discovery of new therapeutic agents for various diseases.
Used in Diagnostic Applications:
The ability of 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT to activate the Epac cAMP receptor makes it a valuable tool for diagnostic purposes. It can be used to assess the functionality of Epac1 and its role in cellular signaling, aiding in the identification of potential biomarkers and the development of diagnostic assays.

Biological Activity

Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC 50 = 2.2 mM), but not PKA (EC 50 > 10 mM). Stimulates Epac-mediated Ca 2+ -mediated Ca 2+ release in pancreatic b-cells in vitro .