51085-49-5

Upstream product

• 348-54-9 2-Fluoroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 100633-89-4 (5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2-fluoro-phenyl)-amine 
• 178469-02-8 2-[3-(2-Fluoro-phenyl)-ureido]-benzoic acid methyl ester 
• 76616-25-6 C₆H₄Cl₃FNP 
• 349-24-6 N-(2-fluorophenyl)-2-(hydroxyimino)acetamide 
• 110821-56-2 (5-Fluoro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-(4-methoxy-phenyl)-methanone 
• 110821-57-3 (4-Bromo-phenyl)-(5-fluoro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 110821-54-0 (4-Chloro-phenyl)-(5-fluoro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 110821-55-1 (5-Fluoro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-p-tolyl-methanone 
• 73628-29-2 2-amino-3-fluorobenzenethiol 
• 20358-06-9 4-fluoro-1,3-benzothiazol-2-amine 
• 656-32-6 N-(2-fluorophenyl)thiourea 
• 38985-64-7 o-fluorophenyl isothiocyanate 
• 1897-87-6 2-methyl-3-(o-fluorophenyl)-4(3H)-quinazolinone 

Relevant academic research and scientific papers

Selective and Additive-Free Hydrogenation of Nitroarenes Mediated by a DMSO-Tagged Molecular Cobalt Corrole Catalyst

We report on the first cobalt corrole that effectively mediates the homogeneous hydrogenation of structurally diverse nitroarenes to afford the corresponding amines. The given catalyst is easily assembled prior to use from 4-tert-butylbenzaldehyde and pyrrole followed by metalation of the resulting corrole macrocycle with cobalt(II) acetate. The thus-prepared complex is self-contained in that the hydrogenation protocol is free from the requirement for adding any auxiliary reagent to elicit the catalytic activity of the applied metal complex. Moreover, a containment system is not required for the assembly of the hydrogenation reaction set-up as both the autoclave and the reaction vessels are readily charged under a regular laboratory atmosphere.

Synthesis of 7-halo indoles (by machine translation)

The present invention relates to synthesis of 7? Halo indole method, comprising the steps of:O-halogenated aniline, chloral hydrate and hydroxylamine hydrochloride by the Sandmeyer reaction to synthesize 7? halogenating isatin ; 7? halogenating isatin dissolved with an organic solvent, in the reducing agent by reduction reaction under the conditions of 7? Halo indole, the reducing agent is an alkali metal borohydride system, four system adopts, lithium hydride system or triethyl silane system. The beneficial effect of the invention is:in order to O-halogenated aniline and the chloral hydrate is, hydroxylamine hydrochloride as raw materials, by the Sandmeyer shall synthesis method for preparing compositions b isonitroso 7? halogenating isatin, and then by further reduction and system reduction to prepare 7? Halo indole; by the 7? Preparation halogenating isatin 7? Halo indole method, the raw material is easy to obtain, low price, higher process yield, the product purity is good, simple operation, and the like, is suitable for batch preparation 7? Halo indole. (by machine translation)

Steric hindrance as a key factor on proton transfer in the σ-adduct forming reactions of o-substituted anilines with 1,3,5-trinitrobenzene in dimethylsulfoxide

Kinetic and equilibrium studies are reported of the reactions of 1,3,5-trinitrobenzene (TNB) with a series of o-substituted anilines in dimethyl sulfoxide (DMSO) in the presence of 1,4-diazabicyclo[2.2.2.]octane (DABCO). The pKa values in DMSO for the aniline derivatives were measured using the proton-transfer equilibrium with 2,4-dinitrophenol. Kinetic studies are compatible with a two-step process involving initial nucleophilic attack on TNB by amine to give a zwitterionic intermediate which may transfer an acidic proton to DABCO to yield the anionic product. The results indicate steric hindrance to proton transfer in reactions involving 2,6-disubstituted anilines.