51089-69-1

Upstream product

• 31837-63-5 benzyl 4-(2-hydroxyethyl)-3,5-dimethylpyrrole-2-carboxylate 

Downstream Products

• 87281-57-0 benzyl 4-(2-cyanoethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 37945-74-7 benzyl 5-acetoxymethyl-4-(2-chloroethyl)-3-methylpyrrole-2-carboxylate 
• 135363-61-0 Benzyl 4-(2-Chloroethyl)-1,3,5-trimethylpyrrole-2-carboxylate 
• 75116-23-3 4-(2-Chloro-ethyl)-3-methyl-5-trichloromethyl-1H-pyrrole-2-carboxylic acid benzyl ester 
• 110995-34-1 benzyl 4-<2-(13C)-cyanoethyl>-3,5-dimethylpyrrole-2-carboxylate 
• 51089-77-1 Benzyl 5-tert-Butoxycarbonyl-4-(2-chloroethyl)-3-methylpyrrole-2-carboxylate 
• 51089-73-7 5-Benzyloxycarbonyl-3-(2-chloroethyl)-4-methylpyrrole-2-carboxylic Acid 
• 51168-54-8 1,6-bis-(2-chloro-ethyl)-2,7-dimethyl-5,10-dioxo-5H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazine-3,8-dicarboxylic acid dibenzyl ester 
• 31862-40-5 3-methyl-7-oxo-1,4,5,7-tetrahydro-pyrano[3,4-b]pyrrole-2-carboxylic acid benzyl ester 
• 130693-49-1 6-(2'-chloroethyl)-1,4,8-triethyl-1',2,3,5,7,8'-hexamethyl-ac-biladiene dihydrobromide 
• 135363-70-1 Dibenzyl 3,4'-Bis(2-chloroethyl)-1,3',4-trimethyldipyrromethane-5,5'-dicarboxylate 
• 135363-62-1 Benzyl 5-Acetoxymethyl-4-(2-chloroethyl)-1,3-dimethylpyrrole-2-carboxylate 
• 63089-18-9 dibenzyl 3,3'-bis-(2-chloroethyl)-4,4'-dimethylpyrromethane-5,5'-dicarboxylate 
• 87377-72-8 dibenzyl 3'-(2-chloroethyl)-4-(2-acetoxyethyl)-3,4'-dimethylpyrromethane-5,5'-dicarboxylate 

Relevant academic research and scientific papers

Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains

In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom

SYNTHESIS OF BILIVERDIN IXγ (PTEROBILIN)

Condensation of a bis(acetoxyethyl)pyrromethane dicarboxylic acid (11d) with a diformylpyrroketone (12b) afforded a bis(acetoxyethyl)-γ-meso-hydroxyporphyrin (13d) which was converted into the related bis(chloroethyl)-γ-benzoyloxyporphyrin (14f).The Zn complex of the latter was transformed by brief treatment with base, followed by chloromethylethyl ether into the zinc bis(chloroethyl)-γ-ethoxymethoxyporphyrin (20b).Dehydrochlorination with potassium t-butoxide in t-butanol, and acid catalysed demetallation and deprotection then afforded the somewhat unstable blue γ-oxyprotoporphyrin dimethyl ester (21).The Fe-complex of the latter readily underwent oxidative ring opening by aerial oxidation in pyridine, and after demetallation gave biliverdin IXγ (pterobilin) dimethyl ester (22).