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511-13-7

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2-chloro-alpha-[2-dimethylaminoethyl]benzhydrol hydrochloride
Cas No: 511-13-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
TIANFU CHEM-- 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE
Cas No: 511-13-7
No Data 1 Kilogram 10 Kilogram/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
Factory direct saleCAS 511-13-7 with best price
Cas No: 511-13-7
USD $ 146.0-176.0 / Gram 10 Gram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
511-13-7 Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-, hydrochloride (1:1)
Cas No: 511-13-7
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-, hydrochloride (1:1) 511-13-7
Cas No: 511-13-7
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
Chlophedianol hydrochloride
Cas No: 511-13-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-, hydrochloride (1:1)
Cas No: 511-13-7
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE CAS: 511-13-7
Cas No: 511-13-7
No Data 1 Gram 3 Metric Ton/Month Qingdao Beluga Import and Export Co., LTD Contact Supplier
Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-, hydrochloride (1:1)
Cas No: 511-13-7
No Data 1 Kilogram 1 Metric Ton/Day Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
CAS NO.511-13-7 Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-, hydrochloride (1:1)
Cas No: 511-13-7
USD $ 50.0-100.0 / Gram 1 Gram 10000 Metric Ton/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier

511-13-7 Usage

Originator

Abehol,Pliva

Uses

A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.

Manufacturing Process

To a suspension of 330.0 g of sodamide (moistened with toluene) in 1500 ml of absolute ether, a solution of 1080.0 g of o-chlorobenzophenone and 350.0 g of acetonitrile in 3500 ml of absolute ether was gradually added dropwise, with stirring, such that the reaction temperature adjusted itself to 28°-30°C. The reaction mixture was stirred for 12 to 15 h at room temperature and was then added carefully to some ice water. The resulting solution was extracted 3 times with ether. The ether solution was washed with water, dried over Na2SO4, filtered, and finally concentrated. When 1 L of petroleum ether was added, 1240.0 g (96% of theoretical) of β-phenyl-β-o-chlorophenylhydroacrylonitrile (melting point 90°-92°C) precipitated. 500.0 g of the β-phenyl-β-o-chlorophenyl-hydroacrylonitrile were dissolved in 3 L of methanol and hydrogenated in the presence of 50.0 g of Raney cobalt at a temperature of 60°-70°C and a pressure of 80-85 ATM. Two moles of hydrogen were absorbed, and after separation of the methanolic solution from the catalyst, 450.0 g of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 of melting point 117°C were obtained. Catalytic methylation of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 (hydrogenation in the presence of 2.2 mol of formaldehyde in aqueous methanol with Raney nickel catalyst) yielded 450.0 g of l-o-chlorophenyl-1- phenyl-3 dimethylaminopropanol-1 of melting point 120°C. In practice it is usually used as hydrochloride.

Brand name

Ulo (3M Pharmaceuticals).

Therapeutic Function

Antitussive
InChI:InChI=1/C17H20ClNO.ClH/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18;/h3-11,20H,12-13H2,1-2H3;1H

511-13-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Clofedanol Hydrochloride

1.2 Other means of identification

Product number -
Other names 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:511-13-7 SDS

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