511-28-4 Usage
Description
Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of
solar ultraviolet irradiation of 7-dehydrocholesterol in the skin.
In 1966, it was first recognized that vitamin
D must undergo activation via two oxidative metabolic steps. The first oxidation to
25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and
is catalyzed by vitamin D 25-hydroxylase. This activation step is not
regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also
is the primary storage form of vitamin D.
Chemical Properties
Pale Yellow Oil
Uses
Vitamin D4 is the active analogue of Vitamin D.
Biological Functions
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D.
The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result
of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the
transport of calcium in each of the target tissues
Active vitamin D works in concert with PTH to enhance active
intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If
serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal
mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize
active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the
24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.
Check Digit Verification of cas no
The CAS Registry Mumber 511-28-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 511-28:
(5*5)+(4*1)+(3*1)+(2*2)+(1*8)=44
44 % 10 = 4
So 511-28-4 is a valid CAS Registry Number.
511-28-4Relevant articles and documents
VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
-
, (2008/06/13)
A process for producing hydroxyvitamin D derivatives, characterized by converting a hydrogen atom or atoms at the 2-position, 24-position, 25-position and/or 26-position of a vitamin D into a hydroxyl group or groups in a solution containing a microorganism that belongs to the genus Nocardia, Streptomyces,Sphingomonas or Amycolata which has an ability to hydroxylate vitamin Ds or an enzyme produced by that microorganism, and optionally under the coexistence of a cyclodextrin; and novel vitamin D3 derivatives obtained by that process.
Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
-
, (2008/06/13)
The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1α-hydroxy vitamin D4 and novel analogues, thereof, including 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4. Novel 1α-hydroxy vitamin D4 compounds and compounds of novel analogues suitable for use in the treatment of such disorders are also disclosed herein.
1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions
-
, (2008/06/13)
Disclosed are new 1α-hydroxy vitamin D7 of formula (I) and 1α-hydroxy vitamin D4 of formula (II) which are useful as active ingredients of pharmaceutical compositions for the treatment of osteoporosis. Those new compounds are synthesized starting from (22E)-5α,8α-(4-phenyl-1,2-urazolo)-6,22-ergostadien-3β-ol 3β-tert-butyl-dimethylsilyl ether and through ten process steps.
