511-98-8 Usage
Uses
Used in Pharmaceutical Industry:
QUININE is used as an antimalarial drug for treating malaria caused by Plasmodium species. It is particularly effective against the parasite's life cycle, disrupting its growth and reproduction.
Used in Medical Industry:
1. QUININE is used as a muscle relaxant to alleviate muscle cramps and spasms, particularly in conditions like nocturnal leg cramps and other muscle-related disorders.
2. It is also used to treat certain types of arrhythmias, specifically those caused by atrial flutter or fibrillation, by stabilizing the heart rhythm and preventing irregular contractions.
Used in Cosmetic Industry:
QUININE is used as a skin-lightening agent in the cosmetic industry. It is included in various skincare products to help reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone.
Used in Food Industry:
1. QUININE is used as a flavoring agent, particularly in the production of tonic water, where it provides the characteristic bitter taste.
2. It is also used as a preservative in the food industry, helping to extend the shelf life of certain products by inhibiting the growth of bacteria and other microorganisms.
Used in Research:
QUININE is used as a research tool in various scientific studies, particularly in the fields of pharmacology, biochemistry, and cell biology. It is employed to investigate the mechanisms of action of different drugs, study the effects of various diseases on cellular processes, and develop new therapeutic strategies for various medical conditions.
References
Schreiber., Planta Med., 6,93 (1958) Alkemeyer, Sandor., Naturwiss., 46, 207 (1959) Schreiber, Adam., Experientia, 17,13 (1961) Schreiber, Adam., Annalen, 666, 155 (1963) Synthesis: Adam, Schreiber., Experientia, 21,471 (1965) Adam, Schreiber., Tetrahedron, 22, 3591 (1966) Absolute configuration: Boll, von Philipsborn., Acta Chem. Scand., 19,1365 (1965)
Check Digit Verification of cas no
The CAS Registry Mumber 511-98-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 511-98:
(5*5)+(4*1)+(3*1)+(2*9)+(1*8)=58
58 % 10 = 8
So 511-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H45NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28-29H,5-15H2,1-4H3/t16-,17+,18+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
511-98-8Relevant academic research and scientific papers
Concise large-scale synthesis of tomatidine, a potent antibiotic natural product
Boudreault, Pierre-Luc,Normandin, Chad
, (2021/10/12)
Tomatidine has recently generated a lot of interest amongst the pharmacology, medicine, and biology fields of study, especially for its newfound activity as an antibiotic agent capable of targeting multiple strains of bacteria. In the light of its low natural abundance and high cost, an efficient and scalable multi-gram synthesis of tomatidine has been developed. This synthesis uses a Suzuki–Miyaura-type coupling reaction as a key step to graft an enantiopure F-ring side chain to the steroidal scaffold of the natural product, which was accessible from low-cost and commercially available diosgenin. A Lewis acid-mediated spiroketal opening followed by an azide substitution and reduction sequence is employed to generate the spiroaminoketal motif of the natural product. Overall, this synthesis produced 5.2 g in a single pass in 15 total steps and 15.2% yield using a methodology that is atom economical, scalable, and requires no flash chromatography purifications.
