51101-80-5

Basic information

• Product Name: 17-hydroxy-10-mercaptoestr-4-en-3-one
• Synonyms: 17-hydroxy-10-mercaptoestr-4-en-3-one
• CAS NO: 51101-80-5
• Molecular Formula: C18H26 O2 S
• Molecular Weight: 306.46
• Mol File: 51101-80-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 470.6°Cat760mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 7.8E-11mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 17-hydroxy-10-mercaptoestr-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxy-10-mercaptoestr-4-en-3-one(51101-80-5)
• EPA Substance Registry System: 17-hydroxy-10-mercaptoestr-4-en-3-one(51101-80-5)

Safety Data

• Hazardous Substances Data: 51101-80-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H26O2S/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h10,13-16,20-21H,2-9H2,1H3/t13-,14-,15-,16-,17-,18?/m0/s1

Upstream product

• 24275-29-4 5α-estran-17β-ol-3-one-5α,10α-oxide, 17-acetate, 3-cyclic ethylene ketal 
• 28838-86-0 C₂₂H₃₃BrO₅ 
• 18367-54-9 3,3-(ethylenedioxy)-5(10)-estren-17β-yl acetate 
• 15342-09-3 17β-hydroxyestr-5(10)-en-3-one ethylene acetal 
• 1089-78-7 17β-hydroxy-estr-5(10)-en-3-one 
• 51101-78-1 5α,17β-dihydroxy-10β-mercaptoestran-3-one ethylene acetal 
• 51101-79-2 5α,17β-dihydroxy-10β-mercaptoestran-3-one 

Relevant articles and documents

Thiol-Containing Androgens as Suicide Substrates of Aromatase

The thiol-containing androgens 17β-hydroxy-10β-mercaptoestr-4-en-3-one (1) and 19-mercaptoandrost-4-ene-3,17-dione (2) were synthesized and tested in human placental microsomes for their ability to suicide inhibit aromatase.Both compounds showed time-dependent, pseudo-first-order rates of inactivation of aromatase with Ki's of 106 and 34 nM and kcat's of 3.2E-3 and 1.2E-3 s-1 respectively for 1 and 2 at 30 deg C.Diffusion dialysis failed to reactivate aromatase previously inactivated by either compound, and both compounds required that NaDPH and O2 be present for time -dependent inactivation of the enzyme.The presence of the substrate, androst-4-ene-3,17-dione (5.0 μM), protected the enzyme from inactivation while cysteine (1.0 mM) failed to protect aromatase from inactivation by either compound.The above evidence demonstrates that both compounds are potent suicide inhibitors of aromatase.