51116-01-9

Usage

Uses

Used in Pharmaceutical Applications:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE is used as a research compound for studying the role of cGMP in cellular processes and signaling pathways. It is particularly useful in understanding the activation of cGMP-dependent protein kinase and its implications in various diseases and conditions.
Used in Cellular Signaling Research:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE is used as a signaling molecule in cellular signaling research to investigate the effects of cGMP on intracellular calcium concentrations. At concentrations ranging from 1 μM to 0.1 mM, it can inhibit acetylcholine-induced increases in intracellular calcium concentrations, providing valuable insights into the regulation of calcium signaling in cells.
Used in Drug Development:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE is used as a potential therapeutic agent in drug development, particularly for conditions where cGMP signaling is dysregulated. Its ability to activate cGMP-dependent protein kinase and modulate intracellular calcium concentrations makes it a promising candidate for the development of new drugs targeting various diseases.
Used in Analytical Chemistry:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE is used as a reference compound in analytical chemistry for the development and validation of methods for the detection and quantification of cGMP and its analogs in biological samples.
Used in Biochemical Assays:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE is used as a reagent in biochemical assays to study the activity of phosphodiesterases and other enzymes involved in the metabolism of cGMP.

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .