511254-92-5

Basic information

• Product Name: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)
• Synonyms: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI);(2S)-1-BENZYL-2-METHYLPIPERAZINE
• CAS NO: 511254-92-5
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28472
• Product Categories: PIPERIDINE
• Mol File: 511254-92-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 282℃
• Flash Point: 112℃
• Appearance: /
• Density: 0.991
• Vapor Pressure: 0.00354mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.29±0.40(Predicted)
• CAS DataBase Reference: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(511254-92-5)
• EPA Substance Registry System: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(511254-92-5)

Safety Data

• Hazardous Substances Data: 511254-92-5(Hazardous Substances Data)

Usage

General Description

Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) is a chemical compound with the molecular formula C12H18N2. It is a derivative of piperazine, a heterocyclic compound commonly used in the pharmaceutical industry as a building block for a variety of drugs. The presence of a methyl group and a phenylmethyl group in the 2nd position of the piperazine ring indicates that this compound may have unique properties and potential applications in drug design and synthesis. Additionally, the (2S) designation indicates that this compound is a stereoisomer with a specific spatial arrangement of its atoms, which may influence its biological activity and interactions with other molecules. Further research and testing are necessary to fully understand the potential uses and effects of this chemical compound.

InChI:InChI=1/C12H18N2/c1-11-9-13-7-8-14(11)10-12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3/t11-/m0/s1

Upstream product

• 147081-29-6 (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 716339-52-5 tert-butyl (3S)-4-benzyl-3-methylpiperazine-1-carboxylate 

Downstream Products

• 716339-53-6 (S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-methylpiperidine-1-carboxylate 
• 306296-78-6 tert-butyl-4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate 
• 869725-68-8 (S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate 
• 511254-95-8 (S)-1-benzyl-4-(4-chlorophenyl)-2-methylpiperazine 
• 1018829-34-9 (2S)-1-benzyl-4-(4-((2S)-4-benzyl-2-methylpiperazin-1-yl)-2-methylphenyl)-2-methylpiperazine 
• 337530-42-4 (3S)-1-(4-chlorophenyl)-3-methylpiperazine 

Relevant articles and documents

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics

(Chemical Equation Presented) The terphenyl structure has been proven to be an ideal scaffold mimicking side-chain functionalities of peptidic α-helices. The synthesis of 1,4-dipiperazino benzenes, using stepwise transition metal-catalyzed N-arylation of chiral piperazines to a central benzene core is reported. The structure determination by X-ray crystallography reveals a geometrical arrangement of the hydrophobic side chains resembling the orientation of key i, i + 3, and i + 7 positions in a peptidic α-helix or in terphenyl helix mimetics.

Piperidine derivatives useful as CCR5 antagonists

The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing