511257-18-4

Basic information

• Product Name: 2-[(E)-Benzyloxyimino]-3-(4-{5-[2-[(E)-benzyloxyimino]-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid ethyl ester
• Synonyms: 2-[(E)-Benzyloxyimino]-3-(4-{5-[2-[(E)-benzyloxyimino]-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid ethyl ester
• CAS NO: 511257-18-4
• Molecular Weight: 1339.72
• Mol File: 511257-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(E)-Benzyloxyimino]-3-(4-{5-[2-[(E)-benzyloxyimino]-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(E)-Benzyloxyimino]-3-(4-{5-[2-[(E)-benzyloxyimino]-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid ethyl ester(511257-18-4)
• EPA Substance Registry System: 2-[(E)-Benzyloxyimino]-3-(4-{5-[2-[(E)-benzyloxyimino]-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid ethyl ester(511257-18-4)

Safety Data

• Hazardous Substances Data: 511257-18-4(Hazardous Substances Data)

Upstream product

• 511257-16-2 2-[(E)-Benzyloxyimino]-3-[3-(4-{2-[(E)-benzyloxyimino]-2-ethoxycarbonyl-ethyl}-2-bromo-5-nitro-phenoxy)-5-bromo-4-methoxy-phenyl]-propionic acid allyl ester 
• 511257-15-1 2-[(E)-Benzyloxyimino]-3-[3-bromo-5-(2-bromo-4-formyl-5-nitro-phenoxy)-4-methoxy-phenyl]-propionic acid allyl ester 
• 511257-14-0 2-[(E)-Benzyloxyimino]-3-[3-bromo-5-(2-bromo-4-formyl-5-nitro-phenoxy)-4-methoxy-phenyl]-propionic acid ethyl ester 
• 511257-09-3 {2-[3-bromo-5-(2-bromo-4-cyanomethyl-phenoxy)-4-methoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 511257-08-2 {2-[3-bromo-5-(2-bromo-4-formyl-phenoxy)-4-methoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 511257-12-8 3-(3-Allyloxy-5-bromo-4-methoxy-phenyl)-2-[(E)-benzyloxyimino]-propionic acid ethyl ester 
• 511257-11-7 3-(3-allyloxy-5-bromo-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-acrylic acid ethyl ester 
• 511257-13-9 2-[(E)-Benzyloxyimino]-3-(3-bromo-5-hydroxy-4-methoxy-phenyl)-propionic acid ethyl ester 
• 511257-07-1 [2-(3-bromo-5-hydroxy-4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 511257-06-0 (3-allyloxy-5-bromo-4-methoxy-phenyl)-acetonitrile 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 23354-30-5 3-bromo-4-methoxy-5-hydroxybenzaldehyde 
• 511257-10-6 (2-{3-[4-(2-amino-ethyl)-2-bromo-phenoxy]-5-bromo-4-methoxy-phenyl}-ethyl)-carbamic acid tert-butyl ester 
• 511257-17-3 2-[(E)-Benzyloxyimino]-3-[3-(4-{2-[(E)-benzyloxyimino]-2-ethoxycarbonyl-ethyl}-2-bromo-5-nitro-phenoxy)-5-bromo-4-methoxy-phenyl]-propionic acid 

Downstream Products

• 511257-19-5 2-benzyloxyimino-3-(4-{5-[2-benzyloxyimino-2-(2-{3-bromo-4-[3-bromo-5-(2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-ethylcarbamoyl)-ethyl]-3-bromo-2-methoxy-phenoxy}-5-bromo-2-nitro-phenyl)-propionic acid pentafluorophenyl ester 

Relevant articles and documents

Synthesis of bastadin analogs through an SNAr coupling strategy

The synthesis of a bastadin-5 analog was achieved in 16% overall yield (16 steps, longest linear sequence) using a strategy of intermolecular SNAr coupling to create diphenyl ether bonds and sequential amide couplings to close the ring. Noteworthy elements include assembly of all four substituted aryl rings from two simple benzaldehydes, strict regiocontrol of meta- versus para-aryl ether bonds and management of the reductively-sensitive aryl bromine substituents.