51134-82-8

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-2-methyl-6-nitro-1H-indole is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the creation of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3-Dihydro-2-methyl-6-nitro-1H-indole serves as a valuable building block for the assembly of complex organic molecules. Its versatility and reactivity make it a useful component in the synthesis of a wide range of organic compounds for various applications.

Upstream product

• 6872-06-6 2-methyl indoline 
• 7664-93-9 sulfuric acid 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 103796-39-0 (±)-2-methylindolin-6-amine 
• 3484-23-9 2-methyl-6-nitro-1H-indole 

Relevant academic research and scientific papers

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6–19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic acid. A qualitative model that accounts for the stereodiscrimination is proposed.

Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds

Protease-activated receptor-1 (PAR-1) is a G-coupled receptor activated by α-thrombin and other proteases. In this paper we describe the synthesis and the pharmacological evaluation of novel peptide-mimetic antagonists (compounds 1-16) characterized by th

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone

A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.