51134-82-8

Basic information

• Product Name: 2,3-Dihydro-2-methyl-6-nitro-1H-indole
• Synonyms: 2,3-Dihydro-2-methyl-6-nitro-1H-indole;6-Nitro-2-methylindoline;2-Methyl-6-nitroindoline
• CAS NO: 51134-82-8
• Molecular Formula: C9H10N2O2
• Molecular Weight: 178.19
• Mol File: 51134-82-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 306.9±31.0 °C(Predicted)
• Appearance: /
• Density: 1.217±0.06 g/cm3(Predicted)
• PKA: 3.45±0.40(Predicted)
• CAS DataBase Reference: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(51134-82-8)
• EPA Substance Registry System: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(51134-82-8)

Safety Data

• Hazardous Substances Data: 51134-82-8(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-2-methyl-6-nitro-1H-indole, also known as CM-398, is an organic compound with a chemical formula C9H10N2O2. It is a nitroindole derivative with a molecular weight of 174.19 g/mol. 2,3-Dihydro-2-methyl-6-nitro-1H-indole is used in the synthesis of various organic molecules and has potential applications in the pharmaceutical industry. It is important to handle this chemical with care, as it may pose health risks if not used properly.

Upstream product

• 6872-06-6 2-methyl indoline 
• 7664-93-9 sulfuric acid 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 3484-23-9 2-methyl-6-nitro-1H-indole 
• 103796-39-0 (±)-2-methylindolin-6-amine 

Relevant articles and documents

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6–19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic acid. A qualitative model that accounts for the stereodiscrimination is proposed.

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone

A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.