51146-73-7

Upstream product

• 85103-35-1 5-(2-nitro-phenyl)-3H-[1,3,4]thiadiazole-2-thione 
• 74-88-4 methyl iodide 
• 552-16-9 ortho-nitrobenzoic acid 
• 832-79-1 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-amine 
• 113111-44-7 2-chloro-5-(2-nitrophenyl)-1,3,4-thiadiazole 
• 85103-35-1 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol 

Downstream Products

• 51805-89-1 2-(5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-aniline 

Relevant academic research and scientific papers

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Synthesis and antifungal activity of 2-aryl-1,3,4-thiadiazole-5-sulphides, sulphoxides and sulphones

2-Aryl-1,3,4-thiadiazole-5-sulphides, sulphoxides and sulphones were synthesized and tested against a variety of fungal strains, Miconazole and fluconazole were used as reference drugs. The most active compounds against Candida albicans, Candida spp., Cryptococcus neoformans and Aspergillus niger were 2-(1-methyl-5-nitro-2-imidazolyl)-5-methylsulphonyl-1 ,3,4-thiadiazole (8h) and 2-(5-nitro-2-furyl)-5-methylsulphonyl-1,3,4-thiadiazole (8f). Our results showed that compounds 8h and 8f were several times more active than fluconazole in most fungal strains.