5115-98-0

Usage

Uses

Used in Pharmaceutical Industry:
PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is utilized as a building block for the creation of different agrochemicals. Its application aids in the development of products designed to enhance crop protection and improve agricultural yields.
Used in Organic Synthesis:
PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is used as a reagent in organic synthesis for the production of complex organic compounds. Its chemical properties make it a valuable asset in the synthesis of a wide range of organic molecules for various applications.
Used in Biological Research:
PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is employed in biological research as an inhibitor of protein-protein interactions. Its potential to modulate these interactions is of interest to scientists studying the underlying mechanisms of various diseases and conditions, possibly leading to the discovery of new therapeutic targets.

InChI:InChI=1/C7H14N2O/c1-8-7(10)6-3-2-4-9-5-6/h6,9H,2-5H2,1H3,(H,8,10)

Upstream product

• 114-33-0 N-Methylnicotinamide 
• 1161364-24-4 benzyl 3-(methylcarbamoyl)piperidine-1-carboxylate 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 885698-91-9 3-methylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.

INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids

The folded structures of peptidomimetics containing dimers of oxanipecotic acid (Oxa) in loop segments were characterized and compared with those of the corresponding nipecotic acid (Nip)-based ones. According to structural studies using FT-IR and NMR spectroscopies, di-oxanipecotic acid adopted more stable turn conformations than di-nipecotic acid, and for tetramers, L,(S)-Oxa,(S)-Oxa,L and L,(S)-Oxa,(R)-Oxa,L formed hairpin-like structures but only L,(R)-Nip,(S)-Nip,L promoted the stable folded conformations.

Facile Reduction of Pyridines with Nickel-Aluminum Alloy

Nickel-aluminum alloy in dilute base can be used to reduce a variety of pyridines, quinolines, and isoquinoline to the corresponding piperidines, 1,2,3,4-tetrahydroquinolines, and 1,2,3,4-tetrahydroisoquinoline in good yield.The reaction is simple to perform, and high temperatures, high pressures, or hydrogen atmospheres are not required.The reaction is accelerated by substituents in the 2-position and by electron-withdrawing groups in the 3- and 4-positions while electron-supplying groups in the 3- and 4-positions retard the reaction.The major product isolated from the reduction of 2-phenylpyridine was 2-cyclohexylpiperidine hydrochloride.With isoniazid (1) and iproniazid (4) the pyridine ring is hydrogenated before the hydrazine is cleaved.