511522-21-7

Basic information

• Product Name: benzyl[2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-3-yl)ethyl]amine
• Synonyms: benzyl[2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-3-yl)ethyl]amine
• CAS NO: 511522-21-7
• Molecular Weight: 268.282
• Mol File: 511522-21-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl[2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-3-yl)ethyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl[2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-3-yl)ethyl]amine(511522-21-7)
• EPA Substance Registry System: benzyl[2,2,2-trifluoro-1-(1-methyl-1H-pyrrol-3-yl)ethyl]amine(511522-21-7)

Safety Data

• Hazardous Substances Data: 511522-21-7(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 96-54-8 N-Methylpyrrole 
• 1997-85-9 N-(2,2,2-trifluoroethylidene)benzylamine 

Relevant articles and documents

BF3-promoted aromatic substitution of N-alkyl α-trifluoromethylated imine: Facile synthesis of 1-aryl-2,2,2-trifluoroethylamines

The aromatic substitution of three representative N-alkyl trifluoromethyl imines 1a-c (R: a, benzyl; b, benzhydryl; c, methyl), obtained from primary alkyl amines and trifluoroacetaldehyde ethyl hemiacetal, was used to investigate the preparation of 1-aryl-2,2,2-trifluoroethylamines. In the presence of BF3·OEt2, the reaction of imine 1 with various aromatic compounds proceeded smoothly at room temperature, giving N-alkyl-1-aryl-2,2,2-trifluoroethylamines in moderate-to-high yields. Moreover, successful regioselective removal of N-benzyl and N-benzhydryl groups was achieved by hydrolysis in hydrochloric acid or by palladium-catalyzed hydrogenolysis.