511540-37-7Relevant academic research and scientific papers
Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor
Pontillo, Joseph,Tran, Joe A.,White, Nicole S.,Arellano, Melissa,Fleck, Beth A.,Marinkovic, Dragan,Tucci, Fabio C.,Saunders, John,Foster, Alan C.,Chen, Chen
, p. 5237 - 5240 (2007/10/03)
Synthesis and structure-activity relationship studies of a series of cyclohexylpiperazines bearing an amide side chain as ligands of the MC4 receptor are discussed. Compounds such as 11i from this series are potent agonists (EC50 = 33 nM, IA = 96%).
Ligands of melanocortin receptors and compositions and methods related thereto
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, (2008/06/13)
Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, m, n, R1, R2, R3a, R3b, R4, R5, R6 W1, W2, W3, W4, Y1, Y2, Y3 and Y4 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
