511546-94-4Relevant academic research and scientific papers
Cyclopalladation of Schiff bases from phenylalanine and 2-phenylglicine
Albert, Joan,Cadena, J. Magali,González, Asensio,Granell, Jaume,Solans, Xavier,Font-Bardia, Mercè
, p. 277 - 283 (2007/10/03)
The action of palladium acetate on the Schiff bases 4-ClC6H4CH=N-CH(R2)COOR1 (R1 = Me, Et; R2 = Ph, CH2Ph), in acetic acid for 3 h at 70 °C and subsequent treatment of the reaction residues with LiCl in acetone, affords the corresponding chlorobridged five-membered endo-metallacycles [PdCl(C-N)]2, 1a, 2a. The action of palladium acetate on the Schiff bases 2,6-Cl2C6H3CH=N-CH (R2)COOR1 (R1 = Me, Et; R2 = Ph, CH2Ph), in chloroform at room temperature and subsequent treatment of the reaction residues with LiCl in acetone, affords the corresponding chloro-bridged five- or six-membered exo-metallacycles, by metallation of the amino acid moiety [PdCl(C-N)]2, 3a-exo, 4a-exo. A small amount of the endo-metallacycles was also obtained, probably by oxidative addition of the ortho C-Cl bond of these imines to Pd(0) formed in situ. Reaction of dimers 1a-4a with PPh3 affords the mononuclear complexes [PdCl(C-N)(PPh3)] 1b-4b.
