5116-45-0 Usage
General Description
1-(2'-deoxy-beta-D-glucopyranosyl)thymine, also known as thymidine, is a nucleoside composed of the pyrimidine base thymine and the sugar deoxyribose. It is a key component of DNA, where it forms base pairs with adenine, and plays a crucial role in genetic information storage and replication. Thymidine is also used in the synthesis of acyclovir, a medication used to treat herpes simplex virus infections. In addition, it is a common precursor in the synthesis of antiretroviral drugs used to treat HIV. Thymidine is important for cell growth and repair and is a fundamental building block for DNA synthesis and repair.
Check Digit Verification of cas no
The CAS Registry Mumber 5116-45-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,1 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5116-45:
(6*5)+(5*1)+(4*1)+(3*6)+(2*4)+(1*5)=70
70 % 10 = 0
So 5116-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O6/c1-5-3-13(11(18)12-10(5)17)8-2-6(15)9(16)7(4-14)19-8/h3,6-9,14-16H,2,4H2,1H3,(H,12,17,18)/t6-,7-,8-,9+/m1/s1
5116-45-0Relevant academic research and scientific papers
Synthesis of 3′-azido-2′,3′Dideoxy-4′-ketohexopyranoid analogues as possible antiviral nucleosides
Khan, Abdul R.,Mulligan, Kimberly X.,Redda, Kinfe K.,Ollapally, Abraham P.
, p. 1023 - 1030 (2007/10/03)
Peracetylated 2-deoxy-D-glucose was coupled with silylated bases. The product was deacetylated and the 4′,6′-hydroxy groups were then protected. An azido group was introduced at the 3′-carbon via tosylation, followed by deprotection, tritylation, and oxid
SYNTHESIS OF TRIDEOXYHEXOPYRANOSYLATED AND HEXENOPYRANOSYLATED NUCLEOSIDE ANALOGUES AS POTENTIAL ANTI-HIV AGENTS
Herdeweijn, P.,Aerschot, A. Van
, p. 895 - 901 (2007/10/02)
The 2-deoxy-D-arabino-hexopyranosyl nucleoside analogues of thymidine, deoxyuridine and deoxycytidine have been prepared by sugar-base condensation and a 3,4-unsaturated bond was introduced via the bisdithiocarbonates.Hydrogenolysis in the presence of Pd
