1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil, also known as 5'-DFUR or doxifluridine, is a chemotherapeutic agent that belongs to the class of fluoropyrimidines. It is a prodrug of 5-fluorouracil (5-FU), a widely used anticancer drug. The molecule consists of a 5-fluorouracil moiety attached to a β-D-2-deoxyglucopyranosyl group, which enhances its oral bioavailability and allows for selective delivery to tumor cells. Once inside the cells, it is metabolized into 5-FU, which inhibits the synthesis of DNA and RNA by incorporating into the nucleic acids and blocking the action of thymidylate synthase, an enzyme essential for DNA synthesis. This leads to the inhibition of tumor growth and cell death. 5'-DFUR is primarily used in the treatment of various types of cancer, including colorectal, breast, and gastric cancers, and is administered orally for better patient compliance.
5116-47-2
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Basic information
- Product Name: 1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil
- Synonyms:
- CAS NO:5116-47-2
- Molecular Formula:
- Molecular Weight: 276.221
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil(5116-47-2)
- EPA Substance Registry System: 1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil(5116-47-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 5116-47-2(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 5116-47-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,1 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.Calculate Digit Verification of CAS Registry Number 5116-47:
(6*5)+(5*1)+(4*1)+(3*6)+(2*4)+(1*7)=72
72 % 10 = 2
So 5116-47-2 is a valid CAS Registry Number.
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5116-47-2Downstream Products
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1-(β-D-2-Deoxyglucopyranosyl)-5-fluorouracil
