51165-68-5

Upstream product

• 21760-98-5 L-valine benzyl ester 
• 2188-18-3 Boc-Arg(NO₂)-OH 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 
• 60526-35-4 N^α-Boc-N^ω-nitro-L-arginine N-hydroxysuccinimide ester 
• 2188-18-3 N-alpha-t-butoxycarbonyl-Ng-nitroarginine 

Downstream Products

• 357429-15-3 N-{N-[(2S)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester 
• 357429-14-2 N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester 
• 148205-72-5 Boc-Pro-Arg(NO₂)-Val-OBzl 
• 149836-37-3 Z-Gly-Pro-arg(NO₂)-Val-OBzl 
• 61067-05-8 H-Gly-Pro-Arg-Val-OH 

Relevant academic research and scientific papers

β-lactam derivatives as enzyme inhibitors: Carboxy peptidyl derivatives of (S)-4-Oxoazetidine-2-carboxylate as peptidomimetics

4-Oxoazetidine-2-carboxylic acid, protected at the nitrogen by silyl groups, was coupled with amino acid and oligopeptide esters. Desilylation and deprotection of the amino acid residues yielded the free β-lactam peptides. Structure and properties were elucidated by spectroscopic methods and discussed. Some selected compounds Were tested as fibrinogen inhibitors and for thrombocyte aggregation. None of the compounds showed any activity up to a concentration of 10-5 Mol/1. Some other compounds exhibited a weak inhibitory activity against elastase (PPE).

Amino acids and peptides. XVII. Synthesis of peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.

Various peptides related to N-terminal portion of fibrin alpha-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal t