5117-44-2

Usage

Uses

Used in Pharmaceutical Research and Development:
PYRAZIN-2-YLACETONITRILE is utilized as a key intermediate in the synthesis of biologically active compounds, contributing to the advancement of new drug formulations. Its structural versatility and potential pharmacological activities make it a valuable asset in the discovery and development of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, PYRAZIN-2-YLACETONITRILE serves as a fundamental building block, facilitating the creation of a wide array of chemical compounds. Its presence in the synthesis process can lead to the production of various organic molecules with diverse applications across different industries.

Upstream product

• 930395-88-3 tert-butyl 2-cyano-2-(pyrazin-2-yl)acetate 

Downstream Products

• 960371-24-8 4-oxo-1-pyrazin-2-yl-cyclohexane-1-carbonitrile 
• 1159734-52-7 1-(pyrazin-2-yl)cyclopropanecarboxylic acid 
• 96129-35-0 3-Phenyl-4-pyrazin-2-yl-isoxazol-5-ylamine 

Relevant academic research and scientific papers

SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES

The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Design of reversible, cysteine-targeted michael acceptors guided by kinetic and computational analysis

Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.