51175-71-4

Basic information

• Product Name: 3-THIOPHENESULFONYL CHLORIDE
• Synonyms: 3-THIOPHENESULFONYL CHLORIDE;3-THIOPHENESULPHONYL CHLORIDE;BUTTPARK 145\50-57;Thiophene-3-sulphonyl chloride;Thiophene-3-sulfonyl chloride;3-(Chlorosulphonyl)thiophene;3-Thienylsulfonyl chloride;Thiophen-3-sulfonyl chloride
• CAS NO: 51175-71-4
• Molecular Formula: C₄H₃ClO₂S₂
• Molecular Weight: 182.65
• Product Categories: Sulphonyl Chlorides;Thiophenes & Benzothiophenes;Sulphonyl Chlorides;Thiophenes & Benzothiophenes
• Mol File: 51175-71-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 44 °C
• Boiling Point: 101-103°C
• Flash Point: 114℃
• Appearance: /
• Density: 1.580
• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Store under Nitrogen
• CAS DataBase Reference: 3-THIOPHENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-THIOPHENESULFONYL CHLORIDE(51175-71-4)
• EPA Substance Registry System: 3-THIOPHENESULFONYL CHLORIDE(51175-71-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 51175-71-4(Hazardous Substances Data)

Usage

General Description

3-Thiophenesulfonyl chloride is an organic compound that consists of a thiophene ring with a sulfonyl chloride functional group attached. It is commonly used as a building block in the synthesis of various organic compounds, particularly in pharmaceutical and agrochemical industries. This chemical is a versatile reagent that can undergo various chemical reactions such as nucleophilic substitution, oxidation, and radical reactions. It is also known for its strong electrophilic nature and is commonly used as a reagent for introducing the sulfonyl chloride moiety into other organic molecules. 3-Thiophenesulfonyl chloride has applications in the synthesis of heterocyclic compounds, dyes, and pharmaceutical compounds due to its ability to introduce functional groups into organic molecules.

InChI:InChI=1/C4H3ClO2S2/c5-9(6,7)4-1-2-8-3-4/h1-3H

Upstream product

• 6165-69-1 Thien-3-ylboronic acid 
• 872-31-1 3-Bromothiophene 
• 858840-32-1 5-iodo-thiophene-2,4-disulfonyl chloride 

Downstream Products

• 33084-49-0 4-bromo-3-methyl-5-aminoisoxazole 
• 881681-44-3 5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881677-32-3 4-methyl-5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 1229097-02-2 N-[4-[1-(4-fluorophenyl)-1H-indazol-5-yl]-3-(trifluoromethyl)-phenyl]-3-thiophenesulfonamide 
• 1447963-70-3 N-cyclohexylthiophene-3-sulfonamide 
• 16718-05-1 3-(phenylsulfonyl)thiophene 
• 1380228-94-3 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-3-sulfonamide 
• 1361215-64-6 1,1,1,3,3,3-hexafluoro-2-(4-(4-(3-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol 
• 1269500-25-5 C₁₉H₂₅N₃O₅S₂ 

Relevant articles and documents

Synthesis of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids

A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

THIENYL-, FURYL- AND PYRROLYL SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN

Thienyl-, furyl-and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl) furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.