alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl), also known as Bis-PEG11-acid, is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media, and the terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
51178-68-8
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Basic information
- Product Name: alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)
- Synonyms: alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl);Polyethylene glycol bis(2-carboxyethyl) ether;Bis-PEG18-acid;Bis-PEG17-acid
- CAS NO:51178-68-8
- Molecular Formula: C30H58O17
- Molecular Weight: 690.77132
- EINECS: N/A
- Product Categories: N/A
- Mol File: 51178-68-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)(CAS DataBase Reference)
- NIST Chemistry Reference: alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)(51178-68-8)
- EPA Substance Registry System: alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)(51178-68-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 51178-68-8(Hazardous Substances Data)
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51178-68-8 Usage
Uses
Used in Pharmaceutical Industry:Bis-PEG11-acid is used as a PEG linker for drug conjugation, improving the solubility, stability, and bioavailability of therapeutic agents. The stable amide bond formed with primary amine groups allows for the attachment of drugs, peptides, or other targeting moieties to the PEG linker.
Used in Bioconjugation:
Bis-PEG11-acid is used as a PEG spacer in bioconjugation applications, such as the attachment of antibodies, enzymes, or other biomolecules to nanoparticles, quantum dots, or other surfaces. The hydrophilic PEG spacer reduces non-specific interactions and increases stability, while the terminal carboxylic acids enable covalent attachment through amide bond formation.
Used in Drug Delivery Systems:
Bis-PEG11-acid is used as a component in the design of drug delivery systems, such as micelles, liposomes, or hydrogels. The PEG linker provides a means to attach drugs or other therapeutic agents to the delivery system, while the hydrophilic nature of PEG enhances solubility and biocompatibility.
Check Digit Verification of cas no
The CAS Registry Mumber 51178-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,7 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.Calculate Digit Verification of CAS Registry Number 51178-68:
(7*5)+(6*1)+(5*1)+(4*7)+(3*8)+(2*6)+(1*8)=118
118 % 10 = 8
So 51178-68-8 is a valid CAS Registry Number.
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51178-68-8Downstream Products
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alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)
