51186-58-4

Basic information

• Product Name: Boc-D-aspartic acid 4-benzyl ester
• Synonyms: T-BUTYLOXYCARBONYL-D-ASPARTIC ACID BETA-BENZYL ESTER;(R)-2-TERT-BUTOXYCARBONYLAMINO-SUCCINIC ACID 1-BENZYL ESTER;N-ALPHA-T-BUTYLOXYCARBONYL-D-ASPARTIC ACID BETA-BENZYL ESTER;N-ALPHA-TERT-BUTYLOXYCARBONYL-D-ASPARTIC ACID BETA-BENZYL ESTER;N-ALPHA-T-BOC-D-ASPARTIC ACID BETA-BENZYL ESTER;N-ALPHA-T-BUTOXYCARBONYL-D-ASPARTIC ACID ALPHA-BENZYL ESTER;BOC-D-ASPARTIC ACID 4-BENZYL ESTER;BOC-D-ASPARTIC ACID ALPHA-BENZYL ESTER
• CAS NO: 51186-58-4
• Molecular Formula: C₁₆H₂₁NO₆
• Molecular Weight: 323.34
• Product Categories: Amino Acids;Aspartic acid [Asp, D];Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 51186-58-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 508.1 °C at 760 mmHg
• Flash Point: 261.1 °C
• Appearance: White to off-white/Powder
• Density: 1.219 g/cm³
• Storage Temp.: Store at 0-5°C
• PKA: 3.65±0.23(Predicted)
• BRN: 2305471
• CAS DataBase Reference: Boc-D-aspartic acid 4-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-aspartic acid 4-benzyl ester(51186-58-4)
• EPA Substance Registry System: Boc-D-aspartic acid 4-benzyl ester(51186-58-4)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 51186-58-4(Hazardous Substances Data)

Usage

Uses

N-Boc-D-aspartic acid 4-benzyl ester is used as an intermediate in organic synthesis and pharmaceuticals.

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 2177-63-1 D-aspartic acid β-benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 157974-00-0 N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide 
• 785024-32-0 (R)-3-Amino-N-phenethyl-succinamic acid benzyl ester 
• 302911-16-6 N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide 
• 1035609-64-3 N-[(R)-3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl]-L-leucine methyl ester 
• 1192595-54-2 (R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester 
• 556069-27-3 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid benzyl ester 
• 556069-25-1 4-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-tert-butoxycarbonylamino-butyric acid benzyl ester 
• 636604-12-1 3-amino-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid benzyl ester 
• 538335-94-3 methyl 2-acetamido-3-[2-(2R)-2-[4-(1-tert-butoxycarbonylpiperidyl-4-oxy)benzoylamino-3-benzyloxycarbonylpropoxy]-4-cyanophenyl]acrylate 
• 538335-95-4 methyl 2-acetamido-3-[2-[(R)-2-[1-(4-pyridyl)piperidine-4-carbonyl]amino-3-benzyloxycarbonylpropoxy]-4-cyanophenyl]acrylate 
• 538335-87-4 methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate 

Relevant articles and documents

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin

A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.

Novel immunological adjuvant compounds and methods of preparation thereof

This application relates to novel immunological adjuvant compounds of the formula: STR1 wherein each of R and R1 are the same or different and are hydrogen or an acyl radical; R2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.