512-64-1 Usage
Uses
Used in Anticancer Applications:
QUINOMYCIN A is used as an antitumor agent for its ability to inhibit the transcription factor hypoxia-inducible factor-1 (HIF-1), which is essential in tumor progression and metastasis.
Used in Pharmaceutical Industry:
QUINOMYCIN A is used as a broad-spectrum antimicrobial agent for its activity against bacteria, fungi, and viruses, making it a valuable compound in the development of new antibiotics and antifungal drugs.
Used in Drug Delivery Systems:
While not explicitly mentioned in the provided materials, given its potent inhibitory effects on HIF-1 and its antitumor properties, QUINOMYCIN A could potentially be used in the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes in cancer treatment.
Biochem/physiol Actions
Echinomycin is an antitumor antibiotic and potent hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the binding of HIF-1α, a transcription factor important in tumor growth. Echinomycin selectively eliminated cancer stem cells in a study with mouse lymphoma and human AML xenogeneic models, eradicating the lymphomas. Recently, echinomycin was also found to act as an antibiotic adjuvant having synergistic effects with novobiocin in gram negative bacteria.
References
1) Kong?et al.?(2005),?Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res.,?65?9047
2) Wang?et al. (2014),?Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood,?124?1127
3) Wang?et al. (2011),?Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell.,?8?399
4) Li?et al. (2015),?Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones,?20?507
Check Digit Verification of cas no
The CAS Registry Mumber 512-64-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 512-64:
(5*5)+(4*1)+(3*2)+(2*6)+(1*4)=51
51 % 10 = 1
So 512-64-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H10O/c1-2-7-5-3-4-6-8(7)9/h3-6,9H,2H2,1H3
