51209-71-3Relevant academic research and scientific papers
Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents
Jeedimalla, Nagalakshmi,Flint, Madison,Smith, Lyndsay,Haces, Alberto,Minond, Dmitriy,Roche, Stéphane P.
supporting information, p. 167 - 179 (2015/11/17)
The aim of this study was the synthesis and lead structure selection of a best anti-leukemic agent from a library of aza-podophyllotoxin analogues (APTs). To this end, we report a scalable, modified multicomponent reaction using a "sacrificial" aniline pa
Mechanistic investigation and implications of a sacrificial aniline for the tandem cascade synthesis of 4-aza-podophyllotoxin analogues
Jeedimalla, Nagalakshmi,Johns, Jennifer,Roche, Stéphane P.
supporting information, p. 5845 - 5848 (2013/10/21)
Mechanistic investigations were pursued to determine a plausible mechanism in the cascade reaction involving tetronic acid with aldehydes and anilines to generate the 4-aza-2,3-dehydropodophyllotoxin core structure. The mechanistic driven hypothesis paved
GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE
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Page/Page column 5-6, (2011/08/22)
The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems.
Aqueous extract of the pericarp of Sapindus trifoliatus fruits: A novel 'green' catalyst for the aldimine synthesis
Pore, Santosh,Rashinkar, Gajanan,Mote, Kavita,Salunkhe, Rajeshri
experimental part, p. 1796 - 1800 (2011/08/05)
The catalytic efficiency in organic synthesis of the aqueous extract of the pericarp of Sapindus trifoliatus fruits was evaluated. The synthesis of a series of aldimines from aromatic aldehydes and amines was successfully catalyzed by the extract, whereas aromatic ketones and amines did not yield ketimines under comparable reaction conditions, indicating the chemoselective catalysis of the extract. The catalytic activity of the extract is due to saponins, which have a common structural skeleton containing a pentacyclic triterpenoid part substituted with different carbohydrate side chains. The mild conditions, high yields, and short reaction times not only make this protocol a valuable alternative to the conventional methods, but it also becomes significant under the roof of environmentally greener and safer processes.
One - Pot Reformatsky-Imine addition reaction-leading to the synthesis of structurally diverse β-lactams
Rajput, Jaspreet,Singh, Baldev,Singal, Kewal Krishan
, p. 643 - 648 (2008/09/18)
The Reformatsky-imine addition reaction of a-bromoethylacetate with aldimines derived from 3,4-methylenedioxy benzaldehyde and α- methylcinnamaldehyde has provided an efficient and practical access to structurally diverse β-lactams. All the new β-lactams
