51217-93-7Relevant academic research and scientific papers
Hydrolysis of Acyl Derivates of Malonaldehyde Dianil. II. Aminolysis and Alcoholysis of Acyl Derivates of Malonaldehyde Dianil and β-Arylaminoacrolein
Ono, Machiko,Tamura, Shinzo
, p. 1443 - 1452 (2007/10/02)
Aminolysis and alcoholysis reactions of β-arylaminoacrolein and its N-acyl derivates were studied.Acid-catalysed aminolysis of β-(N-benzoyl-p-toluidino)acrolein (III) occured at the β-position of III, accompanying the reversible interaction of the amine and the formyl group of III.In the reaction of III and amine in methanol under neutral conditions, aminolysis at the β-position of III and alcoholysis of the amide carbonyl group of III proceeded in parallel; the latter reaction was catalysed by amine.In either case, no evidence of aminolysis at the amide carbonyl group of III was obtained.The reaction of the fotmyl group of III proceeded mainly when III and amine were reacted in benzene solution.Thus, 1-(N-benzoyl-p-methylphenylamino)-3-(p-chlorophenylimino)-1-propene (XII) was obtained when III and p-chloroaniline were reacted in benzene.Alkaline hydrolysis of XII afforded 1-(p-methylphenylamino)-3-(p-chlorophenylimino)-1-propene (XIII), an unsymmetrical malonaldehyd dianil.Aminolysis and alcoholysis reactions of 1-arylamino-3-arylimino-1-propene(malonaldehyde dianil) and its N-acyl-derivates were also studied.Alcoholysis occured at the amide carbonyl group of N-acyl derivates, while aminolysis occured at the 1-position except for the case of 1-(N-phenylcarbamoyl-p-methylphenylamino)-3-(p-methylphenylimino)-1-propene (XIV).Keywords--aminolysis; alcoholysis; β(N-benzoyl-p-toluidino)acrolein; β-(N-phenycarbamoyl-p-toluidino)acrolein; l-(N-benzoyl-p-methylphenylamino)-3-(p-methylphenylimino)-1-propene; l-(N-benzoyl-p-methylphenylamino)-3-(chlorophenylimino)-1-propene; 1-(p-methyphenylamino)-3-(p-chlorophenylimino)-1-propene; 1-(N-phenylcarbamoyl-p-methylphenylamino)-3-(p-methylphenylamino)-3-(p-methylphenylimino)-1-propene
A KINETIC STUDY OF CYCLODEHYDRATION OF β-(p-TOLUIDINO)ACROLEIN. III
Tamura, Shinzo,Todoriki, Reiko (nee Imamura)
, p. 3401 - 3406 (2007/10/02)
The reversible sulfonation at the α-position of β-(p-chloroanilino)acrolein (V) in sulfuric acid at various concentrations was studied kinetically.The rate constants of cyclodehydration of β-(p-toluidino)acrolein (I) with reversible sulfonation at the α-position were evaluated by non-linear least-squares analysis using the rate constants of the reversible sulfonation of V as approximate initial values for those of I.The rate constant k1 of cyclodehydration of I is related to Hammett's acidity function H0 as expressed by the equation log k1 + H0 = -13.97.The rate of cyclodehydration of I is one-fortieth of that of 4-(p-toluidino)-3-penten-2-one (VIII) in sulfuric acid at 25 deg C.Keywords - kinetic study; cyclodehydration; reversible sulfonation; β-(p-chloroanilino)acrolein; β-(p-toluidino)acrolein; 6-methylquinoline; 3-(p-chloroanilino)-1-oxo-2-propene-2-sulfonic acid
