512184-27-9

Upstream product

• 148906-20-1 (4R,5S)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid methyl ester 
• 148843-19-0 (4R,5S)-4-Formyl-5-isopropyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 148843-18-9 (4S,5S)-4-Hydroxymethyl-5-isopropyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 220805-65-2 (2R,3S)-2,3-dihydroxy-4-methylpentanoic acid methyl ester 
• 512184-24-6 (4R,5S)-5-Isopropyl-2,2-dioxo-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid methyl ester 
• 512184-25-7 (2S,3S)-2-azido-3-hydroxy-4-methylpentanoic acid methyl ester 
• 512184-28-0 (4R,5S)-5-Isopropyl-2-oxo-2λ⁴-[1,3,2]dioxathiolane-4-carboxylic acid methyl ester 
• 220805-64-1 methyl (4S,5S)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 87421-21-4 (2S,3S)-3-hydroxyleucine methyl ester 
• 20515-15-5 methyl (2E)-4-methylpent-2-enoate 
• 512184-26-8 (4S,5S)-4-((S)-2-Ethoxycarbonyl-1-hydroxy-2-methyl-propyl)-5-isopropyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 

Downstream Products

• 215232-00-1 α-methylomuralide 

Relevant academic research and scientific papers

A short, stereocontrolled, and practical synthesis of α-methylomuralide, a potent inhibitor of proteasome function

An efficient and practical synthesis of α-methylomuralide (3), a selective inhibitor of proteasomes, has been developed as outlined in Scheme 1. Among the advantages of this route of synthesis over previously described approaches are (1) ease of scale-up