51219-55-7Relevant articles and documents
GLUCOPYRANOSYL DERIVATIVE AND USE THEREOF
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Paragraph 0321-0323, (2020/12/16)
The present invention relates to a glucopyranosyl derivative and a use thereof. In particular, the present invention relates to a glucopyranosyl derivative that is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The present invention further relates to a use of the compound and a pharmaceutical composition thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.
N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents
Low, Eddy,Nair, Satheesh,Shiau, Timothy,Belisle, Barbara,Debabov, Dmitri,Celeri, Chris,Zuck, Meghan,Najafi, Ron,Georgopapadakou, Nafsika,Jain, Rakesh
scheme or table, p. 196 - 198 (2009/05/07)
2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt (2a), a stable derivative of endogenous N,N-dichlorotaurine (1), has been identified and is under development as a topical antimicrobial agent. Structure-activity relationships of analogs were explored to achieve optimal antimicrobial activity with minimal mammalian toxicity while maintaining the desired stability. All the analogs synthesized showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans in the range of 1-128 μg/mL and cytotoxicity against mammalian L929 cells in the range 80-1900 μg/mL.
N-HALOGENATED AMINO COMPOUNDS AND DERIVATIVES
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Page/Page column 84-85, (2008/12/07)
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.