51224-89-6

Basic information

• Product Name: N-(2-ethyl-phenyl)-anthranilic acid
• Synonyms: N-(2-ethyl-phenyl)-anthranilic acid
• CAS NO: 51224-89-6
• Molecular Weight: 241.29
• Mol File: 51224-89-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-ethyl-phenyl)-anthranilic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-ethyl-phenyl)-anthranilic acid(51224-89-6)
• EPA Substance Registry System: N-(2-ethyl-phenyl)-anthranilic acid(51224-89-6)

Safety Data

• Hazardous Substances Data: 51224-89-6(Hazardous Substances Data)

Upstream product

• 578-54-1 ortho-ethylaniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 1488-42-2 Diphenyliodonium-2-carboxylate 

Downstream Products

• 1026484-53-6 2-[ethoxyoxalyl-(2-ethyl-phenyl)-amino]-benzoic acid 
• 35531-49-8 5-Amino-1-ethylacridin 

Relevant articles and documents

Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTT assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy.