51229-59-5

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 874-86-2 4-cyanobenzyl chloride 
• 41037-83-6 (α-Brom-4-cyan-benzyl)-phenyl-sulfon 
• 17201-43-3 4-cyanobenzyl bromide 
• 35525-86-1 4-cyano-N,N-dimethylbenzylamine 
• 41037-88-1 (α-Jod-4-cyan-benzyl)-phenyl-sulfon 
• 41037-77-8 4-(benzenesulfonyl-chloro-methyl)-benzonitrile 

Downstream Products

• 41037-88-1 (α-Jod-4-cyan-benzyl)-phenyl-sulfon 
• 705966-24-1 1-cyano-4-[1-(phenylsulfonyl)ethenyl]benzene 
• 1057717-27-7 C₃₂H₂₅N₂O₄S^(1-)*K⁽¹⁺⁾ 
• 1057717-25-5 4-[1-benzenesulfonyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(4-dimethylaminophenyl)ethyl]benzonitrile 
• 1057717-23-3 4-[1-benzenesulfonyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(julolidin-9-yl)ethyl]benzonitrile 
• 1243693-84-6 C₂₃H₁₄INO₂S 
• 125951-06-6 (E)-4-[2-(phenylsulfonyl)vinyl]benzonitrile 
• 5462-71-5 4-cyanophenylacetic acid 
• 1449768-05-1 C₂₄H₂₇N₃O₅S 
• 1449787-36-3 C₁₄H₁₄N₂O₃S 

Relevant academic research and scientific papers

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).

Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents

The electrophilicity parameters (E) of some trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of enamines and carbanions with known nucleophilicity parameters (N, sN), using the linear free-energy relationship log k2=sN(N+E). The electrophilic reactivities of these reagents cover a range of 17 orders of magnitude, with Shen and Lu's reagent 1 a being the most reactive and Billard's reagent 1 h being the least reactive electrophile. While the observed electrophilic reactivities (E) of the amido-derived trifluoromethylthiolating reagents correlate well with the calculated Gibbs energies for heterolytic cleavage of the X?SCF3 bonds (Tt+DA), the cumol-derived reagents 1 f and 1 g are more reactive than expected from the thermodynamics of the O?S cleavage. The E parameters of the tri/difluoromethylthiolating reagents derived in this work provide an ordering principle for their use in synthesis.

LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS

The invention relates to inhibitors of sphingosine kinase enzymatic activity, compounds and pharmaceutical compositions that inhibit sphingosine kinase 1 and sphingosine kinase 2 (SphK1 and SphK2) enzymes and further relates to methods of treating diseases and disorders mediated by sphingosine 1 phosphate activity, comprising administering an effective amount of sphingosine kinase inhibitors.

Nucleophilic reactivities of benzenesulfonyl-substituted carbanions

Kinetics of the reactions of four benzenesulfonyl-stabilized carbanions (1a-d)- with reference electrophiles (quinone methides 2 and diarylcarbenium ions 3) have been determined in dimethyl sulfoxide solution at 20 °C in order to derive the rea

THIOREDOXIN AND THIOREDOXIN REDUCTASE INHIBITORS

The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.

Expedient Diels-Alder assembly of 4-aryl-4-phenylsulfonyl cyclohexanones

The efficient preparation of 4-aryl-4-phenylsulfonyl cyclohexanones, containing a quaternary sulfone-bearing carbon centre, is described. Their synthesis proceeds in 38-78% overall yield by way of three steps: (i) sulfinate alkylation; (ii) methylenation;