51264-76-7

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Ethoxy-4-formylphenoxy)acetic acid is used as a synthetic reagent for the design, synthesis, and biological evaluation of thiazolidine-2,4-dione conjugates. These conjugates act as PPAR-γ agonists, which are important for the treatment of diabetes. By modulating the activity of PPAR-γ, these conjugates can help regulate glucose metabolism and improve insulin sensitivity, making them valuable in the development of new diabetes treatments.
Used in Chemical Synthesis:
As a vanillin derivative, 2-(2-Ethoxy-4-formylphenoxy)acetic acid can be used as a reagent or reactant in the synthetic preparation of various compounds. Its unique chemical structure allows it to participate in a range of chemical reactions, making it a valuable building block for the creation of new molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 79-11-8 chloroacetic acid 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of thiazolidine-2,4-dione conjugates as PPAR-γ agonists

A library of synthesized conjugates of phenoxy acetic acid and thiazolidinedione 5a-m showed potent peroxisome proliferator activated receptor-γ (PPAR-γ) transactivation as well as significant blood glucose lowering effect comparable to the standard drugs pioglitazone and rosiglitazone. Most of the compounds showed higher docking scores than the standard drug rosiglitazone in the molecular docking study. Compounds 5l and 5m exhibited PPAR-γ transactivation of 54.21 and 55.41%, respectively, in comparison to the standard drugs pioglitazone and rosiglitazone, which showed 65.94 and 82.21% activation, respectively. Compounds 5l and 5m significantly lowered the blood glucose level of STZ-induced diabetic rats. Compounds 5l and 5m lowered the AST, ALT, and ALP levels more than the standard drug pioglitazone. PPAR-γ gene expression was significantly increased by compound 5m (2.00-fold) in comparison to the standard drugs pioglitazone (1.5-fold) and rosiglitazone (1.0-fold). Compounds 5l and 5m did not cause any damage to the liver and could be considered as promising candidates for the development of new antidiabetic agents.

Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.