51269-14-8

Upstream product

• 111-30-8 Glutaraldehyde 
• 38150-01-5 (1α,2β,3α)-2-nitro-1,3-cyclohexanediol 
• 108-24-7 acetic anhydride 

Downstream Products

• 38150-02-6 1,3-Di-O-methyl-2-t-nitrocyclohexan-1r,3c-diol 
• 51254-76-3 1,3-Di-O-benzyl-2t-nitrocyclohexan-1r,3c-diol 
• 19034-91-4 2t-Nitro-1r,3c-bis-cyclohexylamino-cyclohexan 
• 15910-77-7 (trans,trans)-N¹,N³-dibenzyl-2-nitrocyclohexane-1,3-diamine 
• 38150-01-5 (1α,2β,3α)-2-nitro-1,3-cyclohexanediol 
• 108186-61-4 <(1S,2S,3R)-3-hydroxy-2-nitrocyclohexyl>-acetat 
• 51254-75-2 3-Ethoxy-2-nitrocyclohexen 
• 51289-32-8 3-methoxy-2-nitrocyclohex-1-ene 
• 51254-79-6 (2R,6S)-1-Bromo-2,6-dimethoxy-1-nitro-cyclohexane 
• 114454-94-3 <(1R,2R,3S)-3-acetoxy-2-nitrocyclohexyl>-pivalat 
• 114454-95-4 <(1R,2R,3S)-3-hydroxy-2-nitrocylohexyl>-pivalat 
• 114455-01-5 <2,3-dibromo-2-nitrocyclohexyl>-acetat 
• 114454-99-8 (1S,2R,3R)-3-(methoxymethoxy)-2-nitrocyclohexanol 
• 108186-63-6 (S)-2-nitro-2-cyclohexenol 

Relevant academic research and scientific papers

Enantioselective Saponification of Diacetates of 2-Nitro-1,3-propanediols by Pig-Liver Esterase and Preparation of Enantiomerically Pure Derivatives of 2-Nitro-allylic Alcohols (Chiral Multiple-Coupling Reagents)

The reproducible enantioselective saponification of open-chain and cyclic diacetates of meso-2-nitro-1,3-propanediols (see 4b-13b) with pig-liver esterase (PLE) gives monoacetates (see 4c-13c) of >95percent enantiomeric excess.The Re enantiotopic acetate group appears to be saponified preferentially, as proved by the X-ray crystal structure analysis of three camphanoates 4d, 6d, and 7d.Elimination of H2O or AcOH from the hydroxy acetates thus available gives derivatives of nitro-allylic alcohols (see 20-24, 27, and 29) which are subjected to diastereoselective Michael additions or SN2' substitutions.