51274-82-9

Basic information

• Product Name: 1-carboxy-2-(4-chlorophenyl)ethanaminium chloride
• Synonyms: 4-Chlorophenylalanine hydrochloride (1:1); phenylalanine, 4-chloro-, hydrochloride (1:1)
• CAS NO: 51274-82-9
• Molecular Formula: C₉H₁₁Cl₂NO₂
• Molecular Weight: 236.0951
• Mol File: 51274-82-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 339.5°C at 760 mmHg
• Flash Point: 159.1°C
• Vapor Pressure: 3.54E-05mmHg at 25°C
• CAS DataBase Reference: 1-carboxy-2-(4-chlorophenyl)ethanaminium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-carboxy-2-(4-chlorophenyl)ethanaminium chloride(51274-82-9)
• EPA Substance Registry System: 1-carboxy-2-(4-chlorophenyl)ethanaminium chloride(51274-82-9)

Safety Data

• Hazardous Substances Data: 51274-82-9(Hazardous Substances Data)

Upstream product

• 93634-57-2 2-benzoylamino-3-(4-chlorophenyl)acrylic acid 
• 622-95-7 4-chlorobenzyl bromide 
• 20877-13-8 ethyl 2-acetylamino-3-(4-chlorophenyl)-2-cyanopropanoate 
• 6941-36-2 2-acetylamino-2-(4-chlorobenzyl)malonic acid diethyl ester 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 129496-71-5 methyl 2-acetylamino-3-(4-chlorophenyl)propanoate 
• 1575605-43-4 butyl 2-acetylamino-3-(4-chlorophenyl)propanoate 
• 1575605-60-5 allyl 2-acetylamino-3-(4-chlorophenyl)propanoate 
• 1575603-74-5 butyl 2-acetylamino-3-(4-chlorophenyl)propanoate 
• 93634-74-3 N-acetyl-(R)-3-(4-chlorophenyl)alanine methyl ester 
• 93634-74-3 methyl (S)-2-acetamido-3-(4-chlorophenyl)propanoate 
• 14173-40-1 2-amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride 
• 74444-78-3 2-Amino-3-(4-chloro-phenyl)-propionic acid butyl ester; hydrochloride 

Relevant articles and documents

SUBSTITUTED AMINO TRIAZOLES, AND METHODS USING SAME

Disclosed are novel substituted amino triazoles of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of Formula (I) are inhibitors of Acidic mammalian chitinase (AMCase) and are useful, in a non-limiting example, for treating asthma. Also provided are pharmaceutical compositions containing at least one compound of the present invention, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and at least one pharmaceutically acceptable carrier, solvent, adjuvant or diluent, and methods of using such compounds and/or compositions to treat asthma and/or to monitor asthma treatment.

Anthranilic acid based CCK1 receptor antagonists: Preliminary investigation on their second "touch point"

In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that interacting with the N-terminal group. Hence, the modification of the C-terminal pharmacophoric group of our lead VL-0395 can not only enhance the affinity of anthranilic acid derivatives but can modulate the selectivity for one CCK receptor subtype or afford mixed antagonists.

UNUSUAL AMINO ACIDS. III. ASYMMETRIC SYNTHESIS OF 3-ARYLALANINES

21 (Z)-α-N-benzoylamino-β-arylacrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β-arylalanine derivatives with optical yields in the range of 82-95percent ee using the cationi