51276-19-8Relevant academic research and scientific papers
Thiamine biosynthesis in Escherichia coli: Identification of the intermediate and by-product derived from tyrosine
Kriek, Marco,Martins, Filipa,Challand, Martin R.,Croft, Anna,Roach, Peter L.
, p. 9223 - 9226 (2007)
(Chemical Equation Presented) In anaerobic organisms such as E. coli the tyrosine lyase ThiH is essential for the biosynthesis of the thiazole moiety of the vitamin thiamine. ThiH is a member of the radical AdoMet family. The products formed by cleavage of tyrosine in vitro have been identified and suggest a radical-mediated cleavage resulting in p-cresol and dehydroglycine which is hydrolyzed to glyoxylate.
Process for preparing a hydroxyphenylglycine compound
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, (2008/06/13)
Glyoxylic acid or a salt of glyoxylic, an ammonium salt of an organic or inorganic acid and a phenol compound of the formula: STR1 wherein n is an integer of one to three, are condensed together to prepare hydroxyphenylglycine compounds of the formula: STR2 wherein n is the same as defined above. The hydroxyphenylglycine compounds thus obtained are useful as intermediates in the synthesis of penicillins and cephalosporins.
