512783-90-3Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY
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Page/Page column 59; 60; 61, (2019/04/11)
Compounds, and compositions, methods, and uses thereof, are described herein for treating brain injuries.
BETA-LACTAMYL VASOPRESSIN V1A ANTAGONISTS
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Paragraph 0123; 0125, (2018/02/04)
Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.
COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
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Page/Page column 59; 61, (2015/12/23)
Compounds, and compositions, methods, and uses thereof, are described herein for treating neurodegenerative diseases and disorders. In particular, vasopressin receptor modulators, and compositions, methods and uses thereof, are described herein for treati
METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER
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Page/Page column 52, (2012/01/15)
Compounds and compositions are described herein for treating post tramatic stress disorder.
BETA-LACTAM CANNABINOID RECEPTOR MODULATORS
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Page/Page column 91; 93, (2008/06/13)
Described herein are substituted 2-(azetidin-2-on-l-yl)alkanoic acids, alkanedioic acids and 2-hydroxyalkyl alkanoic acids, and 2-acyl alkanoic acids, and derivatives thereof, that are capable of modulating activity at the cannabinoid-1 (CBl) and/or canna
Azetidinones as vasopressin V1a antagonists
Guillon, Christophe D.,Koppel, Gary A.,Brownstein, Michael J.,Chaney, Michael O.,Ferris, Craig F.,Lu, Shi-fang,Fabio, Karine M.,Miller, Marvin J.,Heindel, Ned D.,Hunden, David C.,Cooper, Robin D.G.,Kaldor, Stephen W.,Skelton, Jeffrey J.,Dressman, Bruce A.,Clay, Michael P.,Steinberg, Mitchell I.,Bruns, Robert F.,Simon, Neal G.
, p. 2054 - 2080 (2007/10/03)
The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing h
β -LACTAMYL VASOPRESSIN V2 ANTAGONISTS
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Page/Page column 68; 70, (2010/11/28)
β-lactamyl alkanoic acids and pharmaceutical compositions thereof are described. Methods for treating various diseases and disease states using one or more β-lactamyl alkanoic acids are also described. Substituted 2-(azetidin-2-on-l-yl)alkanedioic acids,
HYDROXY AND KETO-SUBSTITUTED β-LACTAMYL ALKANEDIOIC ACIDS
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Page/Page column 53, (2010/11/28)
3-Hydroxy and 3-keto substituted 2-(azetidin-2-on-l-yl)alkanedioic acids, and analogs and derivatives thereof are described. Methods for using 3-hydroxy and 3-keto substituted 2-(azetidin-2-on-l-yl)alkanedioic acids, and analogs and derivatives thereof, i
BETA-LACTAMYLALKANOIC ACIDS FOR TREATING PREMENSTRUAL DISORDERS
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Page/Page column 28; 30, (2008/06/13)
0-lactamyl alkanoic acids are described. Methods for treating various premenstrual disorders using or more β-lactamyl alkanoic acids are also described.
3-SUBSTITUTED β-LACTAMYL VASOPRESSIN V1A ANTAGONISTS
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Page/Page column 46-47, (2008/06/13)
Novel 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof are described. Methods for using 2-(azetidin-2-on-l-yl)alkanedioic acids and derivatives thereof in the treatment of disease states responsive to antagonism of the vasopressin V1a
