512785-10-3Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY
-
Page/Page column 57; 58, (2019/04/11)
Compounds, and compositions, methods, and uses thereof, are described herein for treating brain injuries.
BETA-LACTAMYL VASOPRESSIN V1A ANTAGONISTS
-
Paragraph 0115; 0119, (2018/02/04)
Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.
METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER
-
Page/Page column 50, (2012/01/15)
Compounds and compositions are described herein for treating post tramatic stress disorder.
BETA-LACTAM CANNABINOID RECEPTOR MODULATORS
-
Page/Page column 88-89, (2008/06/13)
Described herein are substituted 2-(azetidin-2-on-l-yl)alkanoic acids, alkanedioic acids and 2-hydroxyalkyl alkanoic acids, and 2-acyl alkanoic acids, and derivatives thereof, that are capable of modulating activity at the cannabinoid-1 (CBl) and/or canna
Azetidinones as vasopressin V1a antagonists
Guillon, Christophe D.,Koppel, Gary A.,Brownstein, Michael J.,Chaney, Michael O.,Ferris, Craig F.,Lu, Shi-fang,Fabio, Karine M.,Miller, Marvin J.,Heindel, Ned D.,Hunden, David C.,Cooper, Robin D.G.,Kaldor, Stephen W.,Skelton, Jeffrey J.,Dressman, Bruce A.,Clay, Michael P.,Steinberg, Mitchell I.,Bruns, Robert F.,Simon, Neal G.
, p. 2054 - 2080 (2007/10/03)
The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing h
β -LACTAMYL VASOPRESSIN V2 ANTAGONISTS
-
Page/Page column 66-67, (2010/11/28)
β-lactamyl alkanoic acids and pharmaceutical compositions thereof are described. Methods for treating various diseases and disease states using one or more β-lactamyl alkanoic acids are also described. Substituted 2-(azetidin-2-on-l-yl)alkanedioic acids,
HYDROXY AND KETO-SUBSTITUTED β-LACTAMYL ALKANEDIOIC ACIDS
-
Page/Page column 52, (2010/11/28)
3-Hydroxy and 3-keto substituted 2-(azetidin-2-on-l-yl)alkanedioic acids, and analogs and derivatives thereof are described. Methods for using 3-hydroxy and 3-keto substituted 2-(azetidin-2-on-l-yl)alkanedioic acids, and analogs and derivatives thereof, i
BETA-LACTAMYLALKANOIC ACIDS FOR TREATING PREMENSTRUAL DISORDERS
-
Page/Page column 26, (2008/06/13)
0-lactamyl alkanoic acids are described. Methods for treating various premenstrual disorders using or more β-lactamyl alkanoic acids are also described.
3-SUBSTITUTED β-LACTAMYL VASOPRESSIN V1A ANTAGONISTS
-
Page/Page column 44-45, (2008/06/13)
Novel 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof are described. Methods for using 2-(azetidin-2-on-l-yl)alkanedioic acids and derivatives thereof in the treatment of disease states responsive to antagonism of the vasopressin V1a
