512822-27-4

Usage

Uses

Used in Organic Synthesis:
N-Boc-9-azabicyclo[3.3.1]nonan-3-one is used as a chemical reagent for its importance in particular chemical reactions or processes. Its Boc-protected amine function allows for controlled reactions in organic synthesis, making it a valuable component in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Boc-9-azabicyclo[3.3.1]nonan-3-one is used as a building block for the synthesis of complex molecules, including potential drug candidates. Its Boc protection allows for the selective formation of amide bonds and other functional groups, which is crucial in the development of new therapeutic agents.
Used in Research and Development:
N-Boc-9-azabicyclo[3.3.1]nonan-3-one is also used in research and development settings, where it can be employed as a starting material or intermediate in the synthesis of novel compounds. Its unique structure and reactivity make it a valuable tool for exploring new chemical pathways and discovering new molecules with potential applications in various fields.
Safety Considerations:
As with most chemicals, handling N-Boc-9-azabicyclo[3.3.1]nonan-3-one should be done with caution, following safety procedures to prevent potential harm. Proper protective equipment, such as gloves and goggles, should be worn, and the substance should be stored in a secure and appropriate manner to minimize the risk of exposure or accidents.

InChI:InChI=1/C13H21NO3/c1-13(2,3)17-12(16)14-9-5-4-6-10(14)8-11(15)7-9/h9-10H,4-8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 4390-39-0 9-azabicyclo[3.3.1]nonan-3-one 
• 6164-62-1 9-methyl-9-azabicyclo[3.3.1]nonan-3-one hydrochloride 
• 552-70-5 pseudopelletierine 
• 72761-60-5 9-azabicyclo<3.3.1>nonan-3-one hydrochloride 

Downstream Products

• 934180-37-7 tert-butyl (1R,3r,5S)-3-hydroxy-9-azabicyclo[3.3.1]nonane-9-carboxylate 

Relevant academic research and scientific papers

NOVEL 9-AZA-BICYCLO[3.3.1]NON-3-YLOXY CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

This invention relates to novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN

A combination of a steroid sulfatase inhibitor and an ascomycin, which combination is useful as a pharmaceutical.

BICYCLIC FIVE-MEMBERED HETEROARYL DERIVATIVES AND THEIR USE AS RENIN INHIBITORS

The invention relates to novel five-membered heteroaryl derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and especially their use as inhibitors of renin.

ANTI-INFLAMMATORY COMPOUNDS

The use of a steroid sulfatase inhibitor in the preparation of a medicament for the treatment of inflammatory diseases.