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Usage

Uses

Used in Medicinal Chemistry:
[4-(Piperazin-1-yl)phenyl]boronic acid is used as a building block for the synthesis of pharmaceutical compounds due to its ability to form reversible covalent bonds with certain biological targets, which is instrumental in the development of targeted therapies.
Used in Drug Discovery:
In the field of drug discovery, [4-(Piperazin-1-yl)phenyl]boronic acid is utilized for the development of drugs that can modulate specific biological pathways, potentially leading to the creation of novel therapeutic agents.
Used in Organic Synthesis:
[4-(Piperazin-1-yl)phenyl]boronic acid is also used as a versatile reagent in organic synthesis, taking advantage of the unique reactivity of the boronic acid group to facilitate various chemical transformations.
Used in Targeted Therapies Development:
[4-(Piperazin-1-yl)phenyl]boronic acid is employed in the development of targeted therapies, leveraging its capacity to form reversible covalent bonds with biological targets, which can be crucial for the selective action of drugs on disease-causing agents or pathways.
Used in Chemical Intermediates for Drug Development:
As a valuable chemical intermediate, [4-(Piperazin-1-yl)phenyl]boronic acid is used in the synthesis of complex molecules with potential applications in drug development, contributing to the advancement of new medicinal agents.

InChI:InChI=1/C10H15BN2O2/c14-11(15)9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12,14-15H,5-8H2

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 457613-78-4 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid 
• 352437-09-3 tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate 

Downstream Products

• 1443282-47-0 potassium trifluoro(4-(piperazin-1-yl)phenyl)borate 
• 672328-56-2 (2S)-N-(cyanomethyl)-4-methyl-2-{[(S)-(4'-piperazin-1-yl-1,1'-biphenyl-4-yl)(thien-2-yl)methyl]oxy}pentanamide 

Relevant academic research and scientific papers

Recognition of saccharides in the NIR region with a novel fluorogenic boronolectin: in vitro and live cell labeling

This work describes a novel mono-boronic acid derivative of a tricarbocyanine. The probe is a genuine near-infrared fluorescence emitter with improved properties such as a large Stokes shift, excellent water solubility and sensitive fluorogenicity upon bi

Nickel-catalyzed borylation of halides and pseudohalides with tetrahydroxydiboron [B2(OH)4]

Arylboronic acids are gaining increased importance as reagents and target structures in a variety of useful applications. Recently, the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron (BBA) reagent has been reported. The high cost associated with palladium, combined with several limitations of both palladium- and copper-catalyzed processes, prompted us to develop an alternative method. Thus, the nickel-catalyzed borylation of aryl and heteroaryl halides and pseudohalides using tetrahydroxydiboron (BBA) has been formulated. The reaction proved to be widely functional group tolerant and applicable to a number of heterocyclic systems. To the best of our knowledge, the examples presented here represent the only effective Ni-catalyzed Miyaura borylations conducted at room temperature.

Practical asymmetric synthesis of a potent Cathepsin K inhibitor. Efficient palladium removal following Suzuki coupling

A large-scale, chromatography-free synthesis of a potent and selective Cathepsin K inhibitor 1 is reported. The key asymmetric center was installed by addition of (R)-pantolactone to the in situ-generated ketene 4a. The final step of the convergent synthe