51328-45-1Relevant academic research and scientific papers
Titanium catalyzed one-pot multicomponent coupling reactions for direct access to substituted pyrimidines
Majumder, Supriyo,Odom, Aaron L.
experimental part, p. 3152 - 3158 (2010/06/11)
A titanium-catalyzed 3-component coupling reaction can be used to generate tautomers of 1,3-diimines. These diimines produced in situ undergo condensation with amidines in a one-pot procedure to provide substituted pyrimidines. Seventeen examples of pyrimidines are provided using this one-pot, 4-component procedure from simple starting materials. In some cases, catalyst architecture can be tuned to control the regioselectivity of the alkyne addition. Finally, the regioselectivity of amidine addition to unsymmetrical 1,3-diimines is discussed.
Gas-phase thermolysis of thieno[3,2-e][1,2,4]triazines. Interesting routes towards heterocyclic ring systems
Ibrahim, Yehia A.,Al-Awadi, Nouria A.,Ibrahim, Maher R.
, p. 9121 - 9130 (2007/10/03)
Gas-phase thermolysis of thieno[3,2-e][1,2,4]triazines gave benzonitrile, isothiazole, pyrimidine, [1]benzothieno[2,3-d]pyrimidine and thieno[3,2-d]thiazole derivatives. A mechanism of these pyrolytic transformation was proposed. Two new and efficient syntheses of the starting thieno[3,2-e][1,2,4]triazines were reported.
