51335-54-7Relevant articles and documents
Thiocyanation of alkylanilines. A simple and efficient synthesis of thiosulfonates containing 2-aminobenzothiazole
Vara Prasad,Panapoulous,Rubin, John R.
, p. 4065 - 4068 (2007/10/03)
Thiocyanation of anilines was used to introduce a thiol functionality and to construct the aminothiazole ring, all in a single step. A systematic study of thiocyanation of alkyl anilines was investigated to understand the regio-chemistry of the reaction. X-Ray crystal structures of two 2- aminobenzothiazoles were determined to assign the structures without any ambiguity. The intermediates obtained were further expanded to thiosulfonates containing 2-aminobenzothiazoles, which are extremely valuable intermediates to synthesize HIV protease inhibitors. (C) 2000 Elsevier Science Ltd.