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Usage

Uses

Used in Personal Care Products:
Triclosan is used as an antimicrobial agent in various personal care products, such as soaps, toothpaste, and deodorants, for its ability to kill or inhibit the growth of bacteria and fungi, thereby promoting better hygiene and reducing the risk of infections.
Used in Pesticide Industry:
As classified by the Environmental Protection Agency (EPA), triclosan is used as a pesticide to control the growth of microorganisms in various settings, including agricultural and industrial applications.
However, it is important to note that the use of triclosan has been a subject of ongoing debate due to concerns about its potential health and environmental impacts. Some studies have suggested that triclosan may contribute to antibiotic resistance in bacteria and disrupt hormone function in animals. Consequently, there is an ongoing discussion and regulation concerning its inclusion in consumer products, reflecting the need for a balanced approach between its benefits and potential risks.

Upstream product

• 5424-21-5 2,4-dichloro-6-methylpyrimidine 

Downstream Products

• 137161-13-8 2-chloro-4-trichloromethyl-6-trichloromethoxypyrimidine 
• 137161-14-9 2-Chloro-4-methoxy-6-trichloromethylpyrimidine 
• 137161-19-4 2-Fluoro-4-trifluoromethoxy-6-trifluoromethylpyrimidine 

Relevant academic research and scientific papers

New fluoro intermediates for herbicidal sulfonylureas

New pyrimidine and triazine intermediates for herbicidal sulfonylureas are prepared as follows: 2,4-dichloro-6-methylpyrimidine is converted via a halogenation, halogen exchange and substitution sequence to 2-amino-4-trifluoromethyl-6-trifluoromethoxypyrimidine. New fluoromethyl-triazines are available starting from guanidine, trichloroacetonitrile and difluoroacetic anhydride, or alternatively from thiocarbamoyl guanidine and chlorodifluoroacetic ester ring closure. To obtain new o-fluoroalkyl-benzenesulfonamide precursors, o-chlorobenzaldehyde was fluorinated with sulfur tetrafluoride, or a bromobenzene derivative was subjected to a substitution reaction with sodium pentafluoropropionate. Sulfonylureas derived from trifluoromethylpyrimidines with an m-methylthio substituent are selective post-emergence herbicides in cotton, presumably due to sulfone metabolization. Selectivity in wheat is obtained by combining 4-methoxy-6-trifluoromethyl-pyrimidine with a lipophilic difluoromethylbenzenesulfonamide moiety. Also in the difluoromethyl-triazine series, the combination with the difluoromethyl-benzenesulfonamide moiety is a good choice for wheat selectivity. Chlorodifluoromethyl- and trifluoromethyltriazines, however, combine better with an aromatic ester for best activity and selectivity in wheat. Selected compounds are undergoing broad field tests in wheat.